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genmutationstest in vitro på däggdjursceller
in vitro mammalian cell gene mutation test;
Last Update: 2014-11-21
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undersökning av genmutation hos bakterier, kombinerat test avseende strukturella och numeriska kromosomavvikelser i däggdjursceller och genmutationstest på däggdjursceller.
bacterial assay for gene mutation, combined test for structural and numerical chromosome aberrations in mammalian cells and test for gene mutation in mammalian cells.
inga tecken på genotoxicitet sågs i ames mikrobiella mutationstest, i ett genmutationstest på däggdjursceller, eller i ett transformationstest med embryoceller från syrisk hamster.
no evidence of genotoxicity was observed in an ames microbial mutagenicity assay, a mammalian- cell gene mutation assay, and a transformation assay with syrian hamster embryo cells.
capecitabin visade ingen mutagenicitet in vitro i bakterier (ames test) eller i djurceller (kinesiska hamster v79/ hprt genmutationstest).
capecitabine was not mutagenic in vitro to bacteria (ames test) or mammalian cells (chinese hamster v79/ hprt gene mutation assay).
paklitaxel har visat sig vara genotoxiskt in vivo (mikronukleärtest på mus), men det inducerade inte mutagenicitet i ames test eller i genmutationstest på hypoxantin-guaninfosforibosyltranferas från kinesiskt hamsterovarium (cho/hgprt).
paclitaxel has been shown to be genotoxic in vivo (micronucleus test in mice), but it did not induce mutagenicity in the ames test or the chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase (cho/hgprt) gene mutation assay.
