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ingen märkbar toxicitet, såsom immunkomplexmedierad sjukdom eller komplementberoende cytotoxicitet, har iakttagits.
however, no apparent toxicity, such as immune complex-mediated disease or complement-dependent cytotoxicity, was seen.
Last Update: 2017-04-26
Usage Frequency: 3
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dessutom har det visat sig inducera både antikroppsberoende cellmedierad cytotoxicitet (adcc) och komplementberoende cytotoxicitet in vitro.
in addition, it has been shown to induce both antibody dependent cell-mediated cytotoxicity (adcc) and complement-dependent cytotoxicity in vitro.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
dessa studier tyder på att daratumumab kan inducera tumörcellslys genom komplementberoende cytotoxicitet, antikroppsberoende cellmedierad cytotoxicitet och antikroppsberoende cellulär fagocytos vid maligniteter som uttrycker cd38.
these studies suggest that daratumumab can induce tumour cell lysis through complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis in malignancies expressing cd38.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
bindningen av ofatumumab till den membran-proximala epitopen av cd20-molekylen framkallar rekrytering och aktivering av komplement på cellytan, vilket leder till komplementberoende cytotoxicitet och resulterande lys av tumörceller.
the binding of ofatumumab to the membrane-proximal epitope of the cd20 molecule induces recruitment and activation of the complement pathway at the cell surface, leading to complement- dependent cytotoxicity and resultant lysis of tumour cells.
Last Update: 2017-04-26
Usage Frequency: 1
Quality: