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in vitro-studier har visat att dess verkningsmekanism gentemot hiv är dess hämning av hivs omvänt transkriptasenzym, vilket resulterar i ett kedjeavbrott och avbrytande av den virala replikationscykeln.
in vitro studies have demonstrated that its mechanism of action in relation to hiv is inhibition of the hiv reverse transcriptase enzyme, an event which results in chain termination and interruption of the viral replication cycle.
Last Update: 2017-04-26
Usage Frequency: 3
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dolutegravir hämmar hiv-integras genom att binda till integrasets aktiva site och blockera överföringen av dna-strängen vid integreringen av retroviralt dna, ett avgörande steg i hiv-virusets replikationscykel.
dolutegravir inhibits hiv integrase by binding to the integrase active site and blocking the strand transfer step of retroviral deoxyribonucleic acid (dna) integration which is essential for the hiv replication cycle.
Last Update: 2017-04-26
Usage Frequency: 1
Quality: