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cystadane treatment should be supervised by a physician experienced in the treatment of patients with homocystinuria.
cystadane behandling bør overvåges af en læge med erfaring i behandling af patienter med homocysteinuria.
betaine acts as a methyl group donor in the remethylation of homocysteine to methionine in patients with homocystinuria.
betain virker som en methylgruppe- donor i remethyleringen af homocystein til methionin hos patienter med homocysteinuria.
patients with homocystinuria cannot convert homocysteine into cysteine, so homocysteine builds up in the blood and urine.
patienter med homocystinuri kan ikke omdanne homocystein til cystein, hvorfor homocystein ophobes i blodet og i urinen.
cystadane contains betaine anhydrous which is intended to be an adjunctive treatment of homocystinuria, an inborn error of metabolism.
cystadane indeholder betain, vandfrit, der skal bruges som tillægsbehandling af en medfødt fejl i stofskiftet, som kaldes homocysteinuria.
this demonstrates that differences in betaine kinetics are most probably due to betaine depletion in untreated homocystinuria and are only meaningful for the initial treatment.
forskellen i betainkinetikken skyldes sandsynligvis betainmangel hos ubehandlet homocysteinuriapatienter og forskellen har kun betydning i starten af behandlingen.
homocystinuria is an inherited (genetic) disease where the amino acid methionine cannot be broken down completely by the body.
homocystinuri er en arvelig (genetisk) sygdom, hvor aminosyren methionin ikke kan nedbrydes fuldstændigt i organismen.
this included 202 reports that described the effects of cystadane, given at a variety of doses, on homocysteine levels in homocystinuria patients of various ages.
oplysningerne omfattede 202 rapporter, der beskriver virkningerne af cystadane, givet i forskellige doser, på homocysteinniveauet hos patienter i forskellige aldre med homocystinuri.
betaine was shown to lower plasma homocysteine levels in the three types of homocystinuria, i. e.cbs deficiency; mthfr deficiency and cbl defect.
det er påvist, at betain sænker plasma homocystein-niveauerne i tre typer af homocysteinuria, cbs -mangel, mthfr-mangel, og cbl-deffekt.
in homocystinuria, betaine reduces homocysteine levels in the blood by facilitating a reaction in the body called ‘methylation’, which converts homocysteine back into methionine.
ved homocystinuri nedsætter betain homocysteinindholdet i blodet ved at fremme en reaktion, der kaldes methylering, hvorved homocystein tilbagedannes til methionin.
cystadane contains betaine anhydrous which is intended to be an adjunctive treatment of homocystinuria, an inherited (genetic) disease where the amino acid methionine cannot be broken down completely by the body.
cystadane indeholder betain, vandfrit, der skal bruges som tillægsbehandling af homocysteinuria, en nedarvet (genetisk) sygdom, hvor aminosyren methionin ikke kan nedbrydes fuldstændigt af kroppen.
cystadane is used in patients with all three known types of homocystinuria, caused by a lack of the substances required for the breakdown of methionine (‘cystathionine beta-synthase’ [cbs] or ‘5,10- methylene-tetrahydrofolate reductase’[mthfr]), or by defects in ‘cobalamin cofactor metabolism’ (cbl).
cystadane anvendes til patienter med alle tre former for homocystinuri, der skyldes mangel på de stoffer, der nedbryder methionin ("cystathionin-beta-syntase" eller "5,10-methylentetrahydrofolatreduktase") eller defekter i kobalamin-kofaktorstofskiftet.