Usted buscó: norfentanyl (Inglés - Danés)

the major metabolite, norfentanyl is inactive.
hovedmetabolitten norfentanyl er inaktiv.

norfentanyl is not pharmacologically active in animal studies.
i dyreforsøg er norfentanyl ikke farmakologisk aktiv.

fentanyl is metabolised in the liver to norfentanyl by cytochrome cyp3a4 isoform.
fentanyl metaboliseres i leveren til norfentanyl af cytokrom cyp3a4-isoform.

fentanyl is metabolised in the liver and in the intestinal mucosa to norfentanyl by cyp3a4 isoform.
fentanyl metaboliseres i leveren og i tarmenes slimhinder til norfentanyl af cyp3a4- isoformen.

fentanyl is metabolised primarily via cyp3a4 to a number of pharmacologically inactive metabolites, including norfentanyl.
fentanyl metaboliseres primært via cyp3a4 til et antal farmakologisk inaktive metabolitter, herunder norfentanyl.

published literature has indicated that the cyp3a4*22 and cyp3a5*3 single nucleotide polymorphisms influence fentanyl to norfentanyl metabolism with the potential for increased fentanyl exposure in patients with these genetic polymorphs.
det er beskrevet i litteraturen, at enkeltnukleotidpolymorfier (cyp3a4*22 og cyp3a5*3) påvirker fentanyls metabolisering til norfentanyl, hvorved fentanyl-eksponeringen hos patienter med disse genetiske polymorfier potentielt øges.