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on that basis the gacvs considers that pharmacokinetic and developmental studies do not support concerns over the safety of thiomersal in vaccines.
在此基础上,全球疫苗安全咨询委员会认为,药物代谢动力学和不断推进的研究不支持对疫苗中硫柳汞的安全性表示担忧的看法。
expert consultation and data presented to the gacvs indicate that the pharmacokinetic profile of ethyl mercury is substantially different from that of methyl mercury.
专家咨询和提交给全球疫苗安全咨询委员会的数据表明,乙基汞的药物动力学情况同甲基汞大不相同。
a physiologically based pharmacokinetic model for endosulfan metabolism in the male sprague-dawley rats has been developed by chan et al. (2006).
chan等人(2006年)开发了一个针对雄性sprague-dawley大鼠体内硫丹新陈代谢过程的生理药代动力学模型。
in: j. panksepp (ed.) textbook of biological psychiatry. john wiley & sons. 2004, pp. 627-659; j. harro. appendix a: pharmacodynamics and pharmacokinetics.
载于j. panksepp(编)textbook of biological psychiatry. john wiley & sons. 2004. pp 627-659;j. harro appendix a: pharmacodynamics and pharmacokinetics。
since august 2000, the who global advisory committee on vaccine safety (gacvs) has periodically reviewed available information on thiomersal pharmacokinetic studies in humans (including low birthweight infants) and in monkeys and has assessed the validity of animal models in studying associations between thiomersal and neurobehavioural disorders in humans:
2000年8月以来,世卫组织全球疫苗安全咨询委员会定期审查了人(包括出生体重偏低的婴儿)和猴子身上硫柳汞药物代谢动力学研究的现有资料,并在研究人类硫柳汞和神经行为紊乱之间的联系时评估了动物模式的有效性:
this is true even for the us situation, where levels may be 10-20 times those observed in europe, but pharmacokinetics, toxicology, exposure and other critical data are lacking.
即使对美国来说,情况也是如此,美国的水平可能是欧洲观测到的10-20倍,但缺少药物代谢动力学、毒理学、接触及其他关键数据。
this is true even for the us situation, where levels may be 10-20 times those observed in europe, but pharmacokinetics, toxicology, exposure and other critical data are lacking.
即使对美国来说,情况也是如此,美国的水平可能是欧洲观测到的10-20倍,但缺少药物代谢动力学、毒理学、接触及其他关键数据。
this is true even for the us situation, where levels may be 10-20 times those observed in europe, but pharmacokinetics, toxicology, exposure and other critical data are lacking.
虽然那里的暴露水平可能相当于欧洲观测结果的10-20 倍,但有关该化学品的药物动力学、毒理学、暴露水平及其他关键数据仍然十分匮乏。
velsicol chemicals (1980) studied the pharmacokinetics of radiolabelled hbcd (14c-hbcd, purity > 98%) administered to rats as a single oral dose.
维西科化学公司(1980年)研究了以单次经口剂量向大鼠给予放射性标记六溴环十二烷(14c-六溴环十二烷,纯度 > 98%)的药物动力学情况。
the results of a double blind, placebo-controlled, single-centre study of the safety, tolerability and pharmacokinetics of trichlorfon in patients with alzheimer disease were used to calculate the noel for inhibition of erythrocyte cholinesterase activity.
一项采用双盲、安慰剂对照和单中心方法的研究探讨了敌百虫在阿尔兹海默病人体内的安全性、耐受性和药代动力,研究结果用于计算致使红细胞胆碱酯酶活性受抑的无观测效应水平。
the results of a double blind, placebo-controlled, single-centre study of the safety, tolerability and pharmacokinetics of trichlorfon in patients with alzheimer disease were used to calculate the noel for inhibition of erythrocyte cholinesterase activity.
一项采用双盲、安慰剂对照和单中心方法的研究探讨了敌百虫在阿尔兹海默病人体内的安全性、耐受性和药代动力,研究结果用于计算致使红细胞胆碱酯酶活性受抑的无观测效应水平。