Vous avez cherché: demethylation (Anglais - Maltais)

the major route of biotransformation of clomipramine is demethylation to desmethylclomipramine.
ir-rotta ewlenija ta’ bijotrasformazzjoni ta’ clomipramine hi dimetilazzjoni biex jifforma desmethylclomipramine.

sirolimus is extensively metabolised by o-demethylation and/or hydroxylation.
sirolimus huwa metabolizzat estensivament b’o-demethylation u/jew hydroxylation.

major pathways of biotransformation are demethylation and oxidation, followed by conjugation.
triqat maġġuri tal- bijotrasformazzjoni huma demetilizzjoni u ossidazzjoni, segwiti b’ konjugazzjoni.

the main metabolic pathway, n-demethylation, is mediated mainly by cyp3a.
il-passaġġ metaboliku prinċipali, n-demethylation, hu kkontrollat prinċipalment minn cyp3a.

vernakalant is mainly eliminated by cyp2d6 mediated o-demethylation in cyp2d6 extensive metabolisers.
vernakalant jitneħħa prinċipalment permezz ta’ demitilizzazzjoni-o medjata minn cyp2d6 f’metabolizzaturi estensivi ta’ cyp2d6.

o-demethylation and hydroxylation at the 3-oxopiperidinyl moiety are the major sites of biotransformation.
o-demethylation u hydroxylation fil-moiety ta’ 3-oxopiperidinyl huma s-siti maġġuri ta’ bijotrasformazzjoni.

the major routes of metabolism are n-demethylation and hydroxylation, followed by conjugation with sulphate and glucuronic acid.
ir-rotot ewlenin ta’ metaboliżmu huma n-demetilazzjoni u idrosilazzjoni, segwiti konjugazzjoni ma’ sulfat u aċidu glukuroniku.

metabolites identified in faeces were formed via oxidation at the macrocyclic moiety or aromatic moiety or both and by o-demethylation followed by oxidation.
il-metaboliti identifikati fl-ippurgar kienu fformati permezz tal-ossidazzjoni tal-moijetà makroċiklika jew moijetà aromatika jew it-tnejn u b’o-demetilazzjoni segwiti minn ossidazzjoni.

its mode of action is inhibition of fungal cytochrome p450-mediated 14α -sterol demethylation, an essential step in ergosterol biosynthesis.
il - mod ta 'azzjoni tiegħu huwa t- twaqqif ta' 14- sterol demethylation medjata miċ- ċitokromu fungali p450, pass importanti fil- bijosintesi ta 'l- ergosterol.

the principal route of metabolism for nelarabine is o-demethylation by adenosine deaminase to form ara-g, which undergoes hydrolysis to form guanine.
ir- rotta prinċipali ta 'metaboliżmu ta' nelarabine hija o- demetilizzazzjoni b' adensoine deaminase biex jifforma ara- g, li jgħaddi minn idroliżi biex jifforma guanine.

the primary mode of action of voriconazole is the inhibition of fungal cytochrome p450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis.
il-mod primarju ta’ kif jaħdem voriconazole huwa billi jwaqqaf il-14 alpha-lanosterol demethylation medjata miċ-ċitokromu fungali p450, pass essenzjali fil-bijosintesi tal-ergosterol fungali.

the primary metabolites osi-420 and osi-413 of erlotinib produced by o-demethylation of either side chain have comparable potency to erlotinib in non-clinical in vitro assays and in vivo tumour models.
il- metaboliti prinċipali osi-420 u osi-413 ta’ erlotinib riżultat ta’ o-demethylation ta’ waħda mill- katini tal-ġnub għandhom qawwa komparabbli ma’ erlotinib f’testijiet mhux kliniċi in vitro u mudelli tat-tumur in vivo.