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gene activators
فعالکنندههای ژن
Dernière mise à jour : 2013-06-12
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enzyme activators
فعالکنندههای آنزیم
Dernière mise à jour : 2013-06-12
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the immunostimulatory properties of mrna can conversely be increased by the inclusion of an adjuvant to increase the potency of some mrna vaccine for¬mats. these include traditional adjuvants as well as novel approaches that take advantage of the intrinsic immunogenicity of mrna or its ability to encode immune modulatory proteins. self replicating rna vaccines have displayed increased immunogenicity and effectiveness after formulating the rna in a cationic nanoemulsion based on the licensed mf59 (novartis) adjuvant50. another effective adjuvant strategy is trimix, a combina tion of mrnas encoding three immune activator proteins: cd70, cd40 ligand (cd40l) and constitutively active tlr4. trimix mrna augmented the immunogenicity of naked, unmodified, unpurified mrna in multiple cancer vaccine studies and was particularly associated with increased dc maturation and cytotoxic t lympho¬cyte (ctl) responses (reviewed in ref. 51).
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Dernière mise à jour : 2019-01-24
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