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this study used sensitive morphologic evaluation of perfusion-fixed peripheral and central nervous system tissue.
acest studiu a folosit evaluarea morfologică senzorială a ţesutului sistemului nervos periferic şi central, fixat prin perfuzie.
prior to initiation of revolade, examine the peripheral blood smear closely to establish a baseline level of cellular morphologic abnormalities.
Înaintea iniţierii tratamentului cu revolade, trebuie examinat cu atenţie frotiul din sângele periferic pentru a stabili nivelul iniţial al anomaliilor morfologice celulare.
reversible effects consistent with elevated prolactin in rats included decreased weights of ovaries and uterus and morphologic changes in vaginal epithelium and in mammary gland.
la şobolan, efectele reversibile concordante cu creşterea prolactinei au inclus reducerea greutăţii ovarelor şi a uterului şi modificări morfologice ale epiteliului vaginal şi glandei mamare.
it is recommended to perform morphologic and cytogenetic bone marrow examinations in patients at regular intervals (approximately every 12 months).
este recomandabilă efectuarea unor examinări morfologice şi citogenetice ale măduvei osoase la pacienţi, la intervale regulate (aproximativ la intervale de 12 luni).
transient liver function test abnormalities suggestive of hepatic dysfunction, which may be accompanied by morphologic changes on liver biopsy, have been reported in association with ovarian hyperstimulation syndrome.
anomalii tranzitorii ale testelor funcţionale hepatice sugestive pentru disfuncţia hepatică, care pot fi însoţite de modificări morfologice la biopsia hepatică, au fost raportate în asociere cu sindromul de hiperstimulare ovariană.
in patients treated with 6 consecutive monthly injections of eylea 2mg, there was a consistent, rapid and robust morphologic response (as measured by improvements in mean crt) observed.
la pacienţii trataţi cu o injecție de eylea 2 mg lunar, timp de 6 luni consecutiv, s-a observat un răspuns consistent, rapid şi intens în ceea ce priveşte morfologia (măsurată prin îmbunătățirea medie a gcr).
in 3 month studies, evidence of liver toxicity, including elevated enzymes and morphologic alterations, was observed in both rats and monkeys at doses 4- to 6-fold higher than the anticipated clinical therapeutic exposure.
5. 3 date preclinice de siguranţǎ