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addition of a thiol group to o-dealkylated ceritinib was also observed.
pozorovalo sa tiež pridanie tiolovej skupiny k o-dealkylovanému ceritinibu.

two metabolites (a dealkylated and a hydroxylated metabolite) were also identified in urine.
v moči boli identifikované aj 2 metabolity (dealkylovaný a hydroxylovaný metabolit).

oxidative metabolism catalysed by cyp3a4 and cyp2c8 leads to the formation of hydroxylated and dealkylated products.
oxidatívny metabolizmus katalyzovaný cyp3a4 a cyp2c8 vedie k tvorbe hydroxylovaných a dealkylovaných produktov.

it is more than 90 % eliminated by biotransformation to n-dealkylated and hydroxylated inactive metabolites.
viac ako 90% sa eliminuje biotransformáciou na n-dealkylované a hydroxylované neaktívne metabolity.

buprenorphine is metabolised by 14-n-dealkylation and glucuroconjugation of the parent molecule and the dealkylated metabolite.
metabolizmus a eliminácia buprenorfín sa metabolizuje 14- n- dealkyláciou a glukurokonjugáciou materskej molekuly a dealkylovaného metabolitu.

more than 90% of the administered dose of fentanyl is eliminated by biotransformation to n-dealkylated and hydroxylated inactive metabolites.
viac ako 90 % podanej dávky fentanylu sa eliminuje biotransformáciou na n-dealkylované a hydroxylované neaktívne metabolity.

the ‘n-dealkylated acid’ (nw-1689) undergoes conjugation with glucuronic acid yielding its acyl glucuronide.
„n-dealkylovaná kyselina“ (nw-1689) prechádza konjugáciou s kyselinou glukurónovou k acylglukuronidu.

a diastereomer of the hydroxylated derivative, a n-glucuronide of indacaterol, and c- and n-dealkylated products were further metabolites identified.
diastereoizomér hydroxylovaného derivátu, n-glukuronid indakaterolu, a c- a n-dealkylované produkty boli ďalšími identifikovanými metabolitmi.

finally the ‘n-dealkylated acid’ (nw-1689) is formed by oxidative cleavage of the amine bond of either safinamide (minor) or the primary safinamide acid metabolite (nw-1153) (major).
nakoniec „n-dealkylovaná kyselina“ (nw-1689) sa formuje oxidačným štiepením amínovej väzby buď safinamidu (menšie) alebo primárneho metabolitu kyseliny safinamidu (nw-1153) (väčšie).