Vous avez cherché: java coding for kids (Espagnol - Anglais)

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Espagnol

not for kids.

Anglais

not for kids.

Dernière mise à jour : 2018-02-13
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Espagnol

spirituality for kids

Anglais

spirituality for kids

Dernière mise à jour : 2016-11-30
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Espagnol

science news for kids (http://www.sciencenewsforkids.org/)

Anglais

science news for kids (http://www.sciencenewsforkids.org/)

Dernière mise à jour : 2018-02-13
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Espagnol

esto también es cierto para algunos miembros depeachcare for kids®.

Anglais

this is also true for some peachcare for kids® members.

Dernière mise à jour : 2018-02-13
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Espagnol

fundador y presidente de la organización benéfica "futbal for kids ".

Anglais

founder and chairman of the charitable organization "futbal for kids ".

Dernière mise à jour : 2016-11-29
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Espagnol

» 'vendors store weapons for kids' (jamaica observer)

Anglais

» 'vendors store weapons for kids' (jamaica observer)

Dernière mise à jour : 2018-02-13
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Espagnol

¿cómo consigue tech for kids dotar a los niños de habilidades del siglo xxi?

Anglais

how does tech for kids equip children with 21st century skills?

Dernière mise à jour : 2017-04-27
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Espagnol

de 1997 a 1998, protagonizó "popular mechanics for kids" con elisha cuthbert.

Anglais

from 1997 to 1998, he co-hosted "popular mechanics for kids" with elisha cuthbert.

Dernière mise à jour : 2016-03-03
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Espagnol

great websites for kids: es una compilación de witios web ejemplares orientados a los niños de 0 a 14 años.

Anglais

great websites for kids is a compilation of exemplary websites geared to children from birth to age 14.

Dernière mise à jour : 2018-02-13
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Espagnol

68. totally for kids es un programa de radio presentado con la colaboración de niños y dirigido a un público de hasta 13 años.

Anglais

68. "totally for kids " is a radio programme, co-hosted by children for children up to the age of thirteen.

Dernière mise à jour : 2016-11-29
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Espagnol

malcom: yo leí en "times for kids" que los iraquies tienen un plan para terminar con la guerra.

Anglais

malcom: i read in “times for kids” that the iraqis have a plan for ending the war.

Dernière mise à jour : 2018-02-13
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Espagnol

comenzó a tomar clases de teatro en 1999 en un "college for kids" tomó clases durante sus años de escuela intermedia.

Anglais

she started by taking theatre classes in 1999 at a college for kids class during her middle school years.

Dernière mise à jour : 2016-03-03
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Espagnol

el contenido de este boletín informativo es responsabilidad exclusiva de los autores y no representa necesariamente la opinión del departamento de salud y servicios humanos o de ninguna de sus agencias. for teens for kids for parents more on this topic

Anglais

the contents of this newsletter are solely the responsibility of the authors and do not necessarily represent the views of the department of health and human services or any of its agencies.

Dernière mise à jour : 2018-02-13
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Espagnol

(dietary needs for kids with cerebral palsy) los niños con parálisis cerebral tienen problemas con la tonicidad muscular, los movimientos y las habilidades motrices.

Anglais

kids with cerebral palsy (cp) have problems with their muscle tone, movement, and/or motor skills.

Dernière mise à jour : 2018-02-13
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Espagnol

la banda compartió el escenario con bandas como, cute is what we aim for, kids in glass houses, valencia, we the kings, you me at six, y the red jumpsuit apparatus.

Anglais

the group shared the stage with bands such as, cute is what we aim for, kids in glass houses, valencia, we the kings, you me at six and the red jumpsuit apparatus.

Dernière mise à jour : 2016-03-03
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Espagnol

baumhaus verlag es una renombrada editorial que trabaja con éxito en el ámbito internacional publicando libros para niños de entre 3 y 16 años aplicando el lema: "the best for kids".

Anglais

baumhaus verlag is a successful, renowned and internationally active publisher of high quality children’s book for children of age 3-16, operating under the motto: ‘the best for kids’.

Dernière mise à jour : 2018-02-13
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Espagnol

holathe na -ca2 exchanger (ncx) links transmembrane movements of ca2 ions to the reciprocal movement of na ions. it normally functions primarily as a ca2 efflux mechanism in excitable tissues such as the heart, but it can also mediate ca2 influx under certain conditions. na and ca2 ions exert complex regulatory effects on ncx activity. ca2 binds to two regulatory sites in the exchanger’s central hydrophilic domain, and this interaction is normally essential for activation of exchange activity. high cytosolic na concentrations, however, can induce a constitutive activity that bypasses the need for allosteric ca2 activation. constitutive ncx activity can also be induced by high levels of phosphatidylinositol- 4,5-bisphosphate (pip2) and by mutations affecting the regulatory calcium binding domains. in addition to promoting constitutive activity, high cytosolic na concentrations also induce an inactivated state of the exchanger (na -dependent inactivation) that becomes dominant when cytosolic ph and pip2 levels fall. na -dependent inactivation may provide a means of protecting cells from ca2 overload due to ncx-mediated ca2 influx during ischemia. na /ca2 exchange (ncx) is a carrier-mediated transport process that translocates ca2 ions across membranes in an obligatory exchange for na ions. in excitable tissues such as heart and nerve, it functions primarily as a plasma membrane ca2 efflux mechanism, although it can also mediate ca2 influx given the appropriate thermodynamic gradients. ncx activity is regulated principally by the ions that comprise the major determinants of the ncx driving forces, i.e., cytosolic na and ca2 . increases in cytosolic na downregulate ncx activity by inducing an inactive state of the exchanger (na -dependent inactivation), whereas increases in cytosolic ca2 upregulate activity (through allosteric ca2 activation). here we will briefly review the history and molecular biology of na /ca2 exchange, describe the major characteristics of na -dependent inactivation and allosteric ca2 activation, and discuss issues related to the possible physiological roles of these regulatory mechanisms. we will focus mainly on the cardiac isoform of the na /ca2 exchanger (ncx1.1). the na /ca2 exchange family of transporters has been the subject of several recent reviews.1-3 a brief history of na /ca2 exchange the existence of a transporter linking oppositely-directed movements of na and ca2 across the plasma membrane was first described 40 years ago by two groups working (independently and respectively) with squid giant axons4 and guinea pig atria.5 it was immediately recognized that this novel transporter could be crucial to the understanding of the inotropic effects of cardiac glycosides. experimental work in the two decades that followed, done mostly with internally dialyzed squid axons or barnacle muscle, did much to establish the basic features of na /ca2 exchange and its regulation by atp and by cytosolic ca2 (see review by blaustein and lederer6). in 1979, the introduction of plasma membrane vesicles for exchange studies provided an important biochemical tool for further characterization of exchange activity. the stoichiometry of the exchanger was demonstrated to be 3na /1ca2 in null-point studies with vesicles where the electrical potential as a driving force for exchange activity was offset by an oppositely directed na -gradient.7 this value is still generally accepted although there have recently been indications from exchange current measurements of higher stoichiometries.8,9 the situation is complicated by the existence of a na -ca2 co-transport mode of the exchanger which provides an electrogenic na -leak current when na plus ca2 exchanges for ca2 alone.10 the use of plasma membrane vesicles also provided a route for the purification and identification of the exchanger protein using detergent solubilization, protein purification and vesicle reconstitution techniques. philipson and his colleagues11 succeeded in cloning the cardiac exchanger (ncx1) in 1990. the philipson group later described additional genes coding for ncx2 and ncx3 (both expressed primarily in brain and skeletal muscle). the cdna for the na /ca2 exchanger in squid axons, in which so much early work was carried out, was cloned in 1998;12 the squid axon exchanger (ncx-sq1) showed 58% identity to mammalian ncx1. electrical currents due to na /ca2 exchange activity were first demonstrated definitively by kimura et al.13 electrophysiological studies of na /ca2 exchange were markedly enhanced by the use of giant membrane patches, initially from cardiac myocytes and later from xenopus oocytes expressing the exchanger.14,15 the giant patch technology allowed the fluid composition on both sides of the membrane to be controlled and provided access to the cytosolic membrane surface for biochemical modification.

Anglais

hellothe na -ca2 exchanger (ncx) links transmembrane movements of ca2 ions to the reciprocal movement of na ions. it normally functions primarily as a ca2 efflux mechanism in excitable tissues such as the heart, but it can also mediate ca2 influx under certain conditions. na and ca2 ions exert complex regulatory effects on ncx activity. ca2 binds to two regulatory sites in the exchanger’s central hydrophilic domain, and this interaction is normally essential for activation of exchange activity. high cytosolic na concentrations, however, can induce a constitutive activity that bypasses the need for allosteric ca2 activation. constitutive ncx activity can also be induced by high levels of phosphatidylinositol- 4,5-bisphosphate (pip2) and by mutations affecting the regulatory calcium binding domains. in addition to promoting constitutive activity, high cytosolic na concentrations also induce an inactivated state of the exchanger (na -dependent inactivation) that becomes dominant when cytosolic ph and pip2 levels fall. na -dependent inactivation may provide a means of protecting cells from ca2 overload due to ncx-mediated ca2 influx during ischemia. na /ca2 exchange (ncx) is a carrier-mediated transport process that translocates ca2 ions across membranes in an obligatory exchange for na ions. in excitable tissues such as heart and nerve, it functions primarily as a plasma membrane ca2 efflux mechanism, although it can also mediate ca2 influx given the appropriate thermodynamic gradients. ncx activity is regulated principally by the ions that comprise the major determinants of the ncx driving forces, i.e., cytosolic na and ca2 . increases in cytosolic na downregulate ncx activity by inducing an inactive state of the exchanger (na -dependent inactivation), whereas increases in cytosolic ca2 upregulate activity (through allosteric ca2 activation). here we will briefly review the history and molecular biology of na /ca2 exchange, describe the major characteristics of na -dependent inactivation and allosteric ca2 activation, and discuss issues related to the possible physiological roles of these regulatory mechanisms. we will focus mainly on the cardiac isoform of the na /ca2 exchanger (ncx1.1). the na /ca2 exchange family of transporters has been the subject of several recent reviews.1-3 a brief history of na /ca2 exchange the existence of a transporter linking oppositely-directed movements of na and ca2 across the plasma membrane was first described 40 years ago by two groups working (independently and respectively) with squid giant axons4 and guinea pig atria.5 it was immediately recognized that this novel transporter could be crucial to the understanding of the inotropic effects of cardiac glycosides. experimental work in the two decades that followed, done mostly with internally dialyzed squid axons or barnacle muscle, did much to establish the basic features of na /ca2 exchange and its regulation by atp and by cytosolic ca2 (see review by blaustein and lederer6). in 1979, the introduction of plasma membrane vesicles for exchange studies provided an important biochemical tool for further characterization of exchange activity. the stoichiometry of the exchanger was demonstrated to be 3na /1ca2 in null-point studies with vesicles where the electrical potential as a driving force for exchange activity was offset by an oppositely directed na -gradient.7 this value is still generally accepted although there have recently been indications from exchange current measurements of higher stoichiometries.8,9 the situation is complicated by the existence of a na -ca2 co-transport mode of the exchanger which provides an electrogenic na -leak current when na plus ca2 exchanges for ca2 alone.10 the use of plasma membrane vesicles also provided a route for the purification and identification of the exchanger protein using detergent solubilization, protein purification and vesicle reconstitution techniques. philipson and his colleagues11 succeeded in cloning the cardiac exchanger (ncx1) in 1990. the philipson group later described additional genes coding for ncx2 and ncx3 (both expressed primarily in brain and skeletal muscle). the cdna for the na /ca2 exchanger in squid axons, in which so much early work was carried out, was cloned in 1998;12 the squid axon exchanger (ncx-sq1) showed 58% identity to mammalian ncx1. electrical currents due to na /ca2 exchange activity were first demonstrated definitively by kimura et al.13 electrophysiological studies of na /ca2 exchange were markedly enhanced by the use of giant membrane patches, initially from cardiac myocytes and later from xenopus oocytes expressing the exchanger.14,15 the giant patch technology allowed the fluid composition on both sides of the membrane to be controlled and provided access to the cytosolic membrane surface for biochemical modification.

Dernière mise à jour : 2012-04-04
Fréquence d'utilisation : 1
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Référence: Wikipedia

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