Vous avez cherché: hydroxymethylcytosine (Portugais - Anglais)

the amount of hydroxymethylcytosine increases with age, as shown in mouse hippocampus and cerebellum.
the amount of hydroxymethylcytosine increases with age, as shown in mouse hippocampus and cerebellum.

5-hydroxymethylcytosine was originally observed in mammals in 1972 by r. yura, but this initial finding is dubious.
5-hydroxymethylcytosine was originally observed in mammals in 1972 by r. yura, but this initial finding is dubious.

5-hydroxymethylcytosine may be especially important in the central nervous system, as it is found in very high levels there.
5-hydroxymethylcytosine may be especially important in the central nervous system, as it is found in very high levels there.

5-hydroxymethylcytosine has been shown to behave like its precursor, 5-methylcytosine, in bisulfite conversion experiments.
5-hydroxymethylcytosine has been shown to behave like its precursor, 5-methylcytosine, in bisulfite conversion experiments.

he discovered a significant amount of an unknown substance instead, and after conducting several tests, discovered that the substance was 5-hydroxymethylcytosine.
he discovered a significant amount of an unknown substance instead, and after conducting several tests, identified it as being 5-hydroxymethylcytosine.

==localization==every mammalian cell seems to contain 5-hydroxymethylcytosine, but the levels vary significantly depending on the cell type.
==localization==every mammalian cell seems to contain 5-hydroxymethylcytosine, but the levels vary significantly depending on the cell type.

additionally, 5-formylcytosine, an oxidation product of 5-hydroxymethylcytosine and possible intermediate of an oxidative demethylation pathway was detected in dna from embryonic stem cells.
additionally, 5-formylcytosine, an oxidation product of 5-hydroxymethylcytosine and possible intermediate of an oxidative demethylation pathway was detected in dna from embryonic stem cells, although no significant amounts of these putative demethylation intermediates could be detected in mouse tissue.

==history==5-hydroxymethylcytosine was observed by skirmantas kriaucionis, an associate at the heintz lab, who was looking for levels of 5-methylcytosine in two different neurons.
==history==5-hydroxymethylcytosine was observed by skirmantas kriaucionis, an associate at the heintz lab, who was looking for levels of 5-methylcytosine in two different neuron types.