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cox-2, derimod, er hovedsagelig inducerbart og syntetiseres af makrofager og inflammatoriske celler efter stimulation med cytokiner og andre inflammationsmediatorer.
cox-2 on the other hand, is mainly inducible and synthesized by macrophages and inflammatory cells after stimulation by cytokines and other mediators of inflammation.
i kliniske studier hos patienter med psoriasis reducerede apremilast epidermis-fortykkelse af hudlæsionerne, inflammatorisk celleinfiltration og ekspressionen af proinflammatoriske gener, herunder generne for inducerbart nitrogenoxidsyntase (inos), il-12/il- 23p40, il-17a, il-22 og il-8.
in clinical trials in patients with psoriasis, apremilast decreased lesional skin epidermal thickness, inflammatory cell infiltration, and expression of pro-inflammatory genes, including those for inducible nitric oxide synthase (inos), il-12/il-23p40, il-17a, il-22 and il-8.
