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tex pk
tex pk
Ultimo aggiornamento 2011-10-23
Frequenza di utilizzo: 1
Qualità:
pk parameter
interquartile pk parameter
Ultimo aggiornamento 2008-03-04
Frequenza di utilizzo: 4
Qualità:
Attenzione: Questo allineamento potrebbe essere errato.
Eliminalo se ritieni che sia così.
pk/ pd- modellering.
the aim of this study is to investigate: bortezomib pk after single and multiple dose treatment; the mechanisms behind the observed changes in the pk parameters after repeated dosing; any clinically plausible intrinsic factors that may explain and reduce variability; the relationship between body weight/ body surface area/ lean body weight) and pk parameters since dosing regimen is based on bsa; the concentration-proteasome inhibition relationship using pk/ pd-modelling;
bortezomib- pk efter behandling med enkeltdosis
description as an adjunct to the population pharmacokinetics (pk) study nested in the ongoing phase iii trial, the applicant will conduct a clinical pk study in 24 patients with multiple myeloma receiving bortezomib at the doses of 1.0 and 1.3 mg/ m2, twice a week for two weeks followed by a rest period.