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tnf and lymphotoxin exist predominantly as homotrimers, with their biological activity dependent on cross-linking of cell surface tnfrs.
tnf u lymphotoxin jinstabu l- aktar bħala homotrimers, li l- attività bijoloġika tagħhom hija dipendenti fuq “ cross- linking ” ma ’ tnfrs fuq is- superfiċje taċ- ċelluli.
cysteamine mechanism of action by interfering with the cross-linking of collagen fibers has been postulated (see section 4.4).
hu maħsub li cysteamine jista 'jtellef li ssir il- ħolqa ta ’ katina tal- fibri tal- kollaġen (ara sezzjoni 4. 4).
however, the presence of any substances not necessary for the cross-linking, such as extenders, plasticisers and fillers, is not permitted;
iżda, il-preżenza ta’ xi sustanzi mhux meħtiġin għall-inkruċjar, bħal estendituri, plastiċizzaturi u materjali li jimlew, ma hijiex permessa.