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tenofovir diphosphate inhibits hiv-1 reverse transcriptase and the hbv polymerase by direct binding competition with the natural deoxyribonucleotide substrate and, after incorporation into dna, by dna chain termination.
tenofovirdifosfaat remt hiv-1-reverse transcriptase en hbv-polymerase door directe bindingscompetitie met het natuurlijke deoxyribonucleotide-substraat en, na incorporatie in dna, door het beëindigen van de dna-keten.
furthermore, cdatp inhibits ribonucleotide reductase, the enzyme responsible for the conversion of ribonucleotides into deoxyribonucleotides.
bovendien remt cdatp ribonucleotide reductase, het enzym dat verantwoordelijk is voor de omvorming van ribonucleotiden in desoxyribonucleotiden.