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the substance should be examined in a bacteriological (reverse mutation) test with and without metabolic activation.
snov je treba pregledati z bakteriološkim preskusom (povratna mutacija), z metabolično aktivacijo ali brez nje.
a bacterial reverse mutation assay study (“ames test”) was performed with the cysteamine bitartrate used for procysbi and cysteamine bitartrate did not show any mutagenic effects in this test.
opravljen je bil bakterijski test povratnih mutacij (»amesov test«) s cisteaminijevim bitartratom, ki se uporablja za zdravilo procysbi, v katerem cisteaminijev bitartrat ni pokazal mutagenega učinka.
on the other hand, factors which enhance the sensitivity of the bacterial reverse mutation test can lead to an overestimation of mutagenic activity.
po drugi strani pa lahko dejavniki, ki povečajo občutljivost preizkusa bakterijskih povratnih mutacij, privedejo do precenitve mutagenega delovanja.
atazanavir was negative in an ames reverse-mutation assay but did induce chromosomal aberrations in vitro in both the absence and presence of metabolic activation.
amesov test reverznih mutacij je bil za atazanavir negativen, toda in vitro so odkrili pojav kromosomskih aberacij, in sicer tako s presnovno aktivacijo kot brez nje.