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dosisgelimiteerde toxiciteit was hematologisch en werd gemeld bij elke dosis, maar is logischerwijs ernstiger bij hogere doses.
dose-limiting toxicity was haematological and was reported with any dose but is expected to be more severe at higher doses.
Ultimo aggiornamento 2017-04-26
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dosisgelimiteerde toxiciteit was hematologisch en werd gemeld bij elke dosis, maar er wordt verwacht dat ze ernstiger is bij hogere doses.
dose-limiting toxicity was haematological and was reported with any dose but is expected to be more severe at higher doses.
Ultimo aggiornamento 2017-04-26
Frequenza di utilizzo: 1
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gebaseerd op dosisgelimiteerde toxiciteit van myelosuppressie was de maximale verdragen dosis (mtd) vastgesteld op 2,0 mg/m2 /dag met g-csf en 1,4 mg/m2/dag zonder g-csf in een farmacokinetiekonderzoek bij kinderen met refractaire solide tumoren (zie rubriek 5.2).
based on the dose-limiting toxicity of myelosuppression, the maximum tolerated dose (mtd) was established at 2.0 mg/m2/day with g-csf and 1.4 mg/m2/day without g- csf in a pharmacokinetic study in paediatric patients with refractory solid tumours (see section 5.2).
Ultimo aggiornamento 2017-04-26
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