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vitamine d3 wordt snel verdeeld, voornamelijk naar de lever waar het wordt omgezet in 25-hydroxyvitamine d3, de belangrijkste opslagvorm.
vitamin d3 is rapidly distributed mostly to the liver where it undergoes metabolism to 25-hydroxyvitamin d3, the major storage form.
biotransformatie vitamine d3 wordt in de lever snel door hydroxylering omgezet in 25-hydroxyvitamine d3, en daarna in de nieren omgezet in 1,25-dihydroxyvitamine d3, de biologisch actieve vorm.
biotransformation vitamin d3 is rapidly metabolized by hydroxylation in the liver to 25-hydroxyvitamin d3, and subsequently metabolized in the kidney to 1,25-dihydroxyvitamin d3, which represents the biologically active form.
na 15 weken behandeling waren de gemiddelde serumconcentraties 25-hydroxyvitamine d in de groep met adrovance (70 mg/ 2800 ie) (56 nmol/ l [23 ng/ ml] significant hoger (26%) dan in de groep met alleen alendronaat (46 nmol/ l [18,2 ng/ ml]).
after 15 weeks of treatment, the mean serum 25-hydroxyvitamin d levels were significantly higher (26%) in the adrovance (70 mg/ 2800 iu) group (56 nmol/ l [23 ng/ ml]) than in the alendronate-only group (46 nmol/ l [18.2 ng/ ml]).