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di berawird bi vayrûsên yek-zincîrî ya rna ya din, qasa texmînyar guherîn dibe “navendî” bi “bilind” berçav bibe, û navencîya qasa guherîn bi ~10-4 ji bo her sal bi ciha 2 be, li ser essasa gava guncandina cov bi mazuvanê nû.
in comparison to other single-stranded rna viruses, the estimated mutation rates of covs could be regarded as “moderate” to “high” with an average substitution rate being ~10-4 substitution per year per site 2, depending on the phase of cov adaptation to novel hosts.