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apa ini masih ada
这个还有吗
最終更新: 2022-02-19
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kabari aku jika ada waktu
最終更新: 2021-02-05
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selama stock masih ada.
while stock is still in stock
最終更新: 2024-06-09
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masih ada yang ditutupi dari saya
the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors. the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors.
最終更新: 2014-04-24
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berlaku selama persediaan masih ada
while supplies last
最終更新: 2019-04-12
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tidak ada waktu untuk bercinta lagi
no time to make love again
最終更新: 2023-06-25
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dia menjawab: "masih ada tambahan?"
it will say, "are there any more (to come)?"
最終更新: 2014-07-03
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警告:見えない HTML フォーマットが含まれています
tidak ada waktu untuk bercinta demi cita cita
there is no time to make love for the sake of ideals
最終更新: 2023-10-14
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sibuk kerja tidak ada waktu untuk bercinta
no time to make love because of busy work
最終更新: 2023-11-12
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aku berharap suatu saat nanti ada waktu buat kita bisa kembali
i hope someday there is a time for us to be back
最終更新: 2015-12-25
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masih berada di episode menunggu
masih berada di episode menunggu
最終更新: 2024-01-26
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semua ada waktunya
everything has its own time
最終更新: 2020-11-01
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maka waktu itu adalah waktu (datangnya) hari yang sulit,
that day will be a difficult day
最終更新: 2014-07-03
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saya bangun pagi pukul 06.00 pagi, sebelum mandi jika berantakan akan merapikan tempat tidur, selanjut nya saya mandi, setelah selesai berkemas dan masih ada waktu, sayakan untuk sarapan sebelum pembelajaran dimulai.
saya bangun pagi pukul 06.00 pagi, sebelum mandi jika berantakan saya akan merapikan tempat tidur, selanjut nya saya mandi, setelah selesai berkemas dan masih ada waktu, saya sempatkan untuk sarapan sebelum pembelajaran daring dimulai.
最終更新: 2021-08-12
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