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der anteil tödlich verlaufender blutungen war 0,2% für prasugrel und 0,1% für clopidogrel.
in patients ≥ 60 kg and age < 75 years, non-cabg-related timi major or minor bleeding rates were 3.6% for prasugrel and 2.8% for clopidogrel; rates for fatal bleeding were 0.2% for prasugrel and 0.1% for clopidogrel.
bei gesunden probanden verringerte prasugrel die exposition von hydroxybupropion, ein cyp2b6 metabolit des bupropions um 23%.
in healthy subjects, prasugrel decreased exposure to hydroxybupropion, a cyp2b6-mediated metabolite of bupropion, by 23%.