검색어: aminométhylbenzothiazol (프랑스어 - 독일어)

conjugué d'effecteurs selon la revendication 1 ou 2, caractérisé en ce que l'élément effecteur est choisi dans le groupe constitué de : (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[1-méthyl-2-(2-méthylthiazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxyméthylthiazol-4-yl)-1-méthylvinyl]-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(e))-16-[2-(2-aminométhylthiazol-4-yl)-1-méthylvinyl]-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[1-méthyl-2-(2-méthylthiazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthylthiazol-4-yl)-1-méthylvinyl]-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo-[14,1,0]heptadécane-5,9-dione ; (1s, 3s(e), 7s, 10r, 11s, 12s, 16r)-3-[2-(2-aminométhylthiazol-4-yl)-1-méthylvinyl]-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo-[14,1,0]heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[1-méthyl-2-(2-méthylthiazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s, 7r, 8s, 9s, 13z, 16s(e))-4,8-dihydroxy-16-[2-(2-hydroxyméthylthiazol-4-yl)-1-méthylvinyl]-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s, 7r, 8s, 9s, 13z, 16s(e))-16-[2-(2-aminométhylthiazol-4-yl)-1-méthylvinyl]-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[1-méthyl-2-(2-méthylthiazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthylthiazol-4-yl)-1-méthylvinyl]-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminométhylthiazol-4-yl)-1-méthylvinyl]-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[1-fluoro-2-(2-méthylthiazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxyméthylthiazol-4-yl)-1-fluorovinyl]-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s, 7r, 8s, 9s, 13z, 16s (z))-16-[2- (2-aminométhylthiazol-4-yl)-1-fluorovinyl]-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[1-fluoro-2-(2-méthylthiazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,o]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthylthiazol-4-yl)-1-fluorovinyl]-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminométhylthiazol-4-yl)-1-fluorovinyl]-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[1-chloro-2-(2-méthylthiazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxyméthylthiazol-4-yl)-1-chlorovinyl]-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminométhylthiazol-4-yl)-1-chlorovinyl]-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s, 3s (z), 7s, 10r, 11s, 12s, 16r)-7,11-dihydroxy-8, 8, 10, 12, 16-pentaméthyl-3-[1-chloro-2-(2-méthylthiazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]heptadécane-5,9-dione ; (1s, 3s(z), 7s, 10r, 11s, 12s, 16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthylthiazol-4-yl)-1-chlorovinyl]-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminométhylthiazol-4-yl)-1-chlorovinyl]-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[1-fluoro-2-(2-méthylthiazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,132,165(z))-4,8-dihydroxy-16-[2-(2-hydroxyméthylthiazol-4-yl)-1-fluorovinyl]-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminométhylthiazol-4-yl)-1-fluorovinyl]-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[1-fluoro-2-(2-méthylthiazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthylthiazol-4-yl)-1-fluorovinyl]-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminométhylthiazol-4-yl)-1-fluorovinyl]-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[1-chloro-2-(2-méthylthiazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxyméthylthiazol-4-yl)-1-chlorovinyl]-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminométhylthiazol-4-yl)-1-chlorovinyl]-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[1-chloro-2-(2-méthylthiazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthylthiazol-4-yl)-1-chlorovinyl]-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo(14.1.0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminométhylthiazol-4-yl)-1-chlorovinyl]-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[1-méthyl-2-(2-pyridyl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[1-méthyl-2-(2-pyridyl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[1-méthyl-2-(2-pyridyl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[1-méthyl-2-(2-pyridyl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[1-fluoro-2-(2-pyridyl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[1-fluoro-2-(2-pyridyl)-vinyl]-4,17-dioxabicyclo[14.1.0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s (z))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[1-chloro-2-(2-pyridyl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (1 s ,3 s (z), 7 s ,10r,11s,12 s , 16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[1-chloro-2-(2-pyridyl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[1-fluoro-2-(2-pyridyl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[1-fluoro-2-(2-pyridyl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s, 7r, 8s, 9s, 13z, 16s(z))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[1-chloro-2-(2-pyridyl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[1-chloro-2-(2-pyridyl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7;9,13-pentaméthyl-16-[1-méthyl-2-(2-méthyloxazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxyméthyloxazol-4-yl)-1-méthylvinyl]-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(e))-16-[2-(2-aminométhyloxazol-4-yl)-1-méthylvinyl]-4,8-dihydroxy-5, 5, 7, 9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[1-méthyl-2-(2-méthyloxazol-4-yl)-vinyl]-4,17-dioxabicyclo [14,1,0]-heptadécane-5,9-dione ; (1s, 3s (e), 7s, 10r, 11s, 12s, 16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthyloxazol-4-yl)-1-méthylvinyl]-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo [14,1,0]-heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminométhyloxazol-4-yl)-1-méthylvinyl]-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[1-méthyl-2-(2-méthyloxazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxyméthyloxazol-4-yl)-1-méthylvinyl]-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(e))-16- [2- (2-aminométhyloxazol-4-yl)-1-méthylvinyl]-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[1-méthyl-2-(2-méthyloxazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthyloxazol-4-yl)-1-méthylvinyl]-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminométhyloxazol-4-yl)-1-méthylvinyl]-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[1-fluoro-2-(2-méthyloxazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxyméthyloxazol-4-yl)-1-fluorovinyl]-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminométhyloxazol-4-yl)-1-fluorovinyl]-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[1-fluoro-2-(2-méthyloxazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthyloxazol-4-yl)-1-fluorovinyl]-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14.1.0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminométhyloxazol-4-yl)-1-fluorovinyl]-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[1-chloro-2-(2-méthyloxazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxyméthyloxazol-4-yl)-1-chlorovinyl]-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminométhyloxazol-4-yl)-1-chlorovinyl]-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[1-chloro-2-(2-méthyloxazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthyloxazol-4-yl)-1-chlorovinyl]-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14, 1, 0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminométhyloxazol-4-yl)-1-chlorovinyl]-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[1-fluoro-2-(2-méthyloxazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxyméthyloxazol-4-yl)-1-fluorovinyl]-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminométhyloxazol-4-yl)-1-fluorovinyl]-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s, 3s(z), 7s, 10r, 11s, 12s, 16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[1-fluoro-2-(2-méthyloxazol-4-yl)-vinyl]-4,17-dioxabicyclo[14.1.0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthyloxazol-4-yl)-1-fluorovinyl]-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminométhyloxazol-4-yl)-1-fluorovinyl]-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[1-chloro-2-(2-méthyloxazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxyméthyloxazol-4-yl)-1-chlorovinyl]-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminométhyloxazol-4-yl)-1-chlorovinyl]-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[1-chloro-2-(2-méthyloxazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthyloxazol-4-yl)-1-chlorovinyl]-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminométhyloxazol-4-yl)-1-chlorovinyl]-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[2-(2-méthylthiazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxyméthylthiazol-4-yl)-vinyl]-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(e))-16-[2-(2-aminométhylthiazol-4-yl)-vinyl]-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[2-(2-méthylthiazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthylthiazol-4-yl)-vinyl]-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminométhylthiazol-4-yl)-vinyl]-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[2-(2-méthylthiazol-4-yl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxyméthylthiazol-4-yl)-vinyl]-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s, 7r, 8s, 9s, 13z, 16s(e))- 16-[2-(2-aminométhylthiazol-4-yl)-vinyl]-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s, 3s(e), 7s, 10r, 11s, 12s, 16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[2-(2-méthylthiazol-4-yl)-vinyl]-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxyméthylthiazol-4-yl)-vinyl]-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminométhylthiazol-4-yl)-vinyl]-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-[2-(2-pyridyl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-[2-(2-pyridyl)-vinyl]-4,17-dioxabicyclo[14,1,0]heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-[2-(2-pyridyl)-vinyl]-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-[2-(2-pyridyl)-vinyl]-4,17-dioxabicyclo[14,1,0]heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-16-(2-méthylbenzothiazol-5-yl)-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxyméthylbenzothiazol-5-yl)-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s, 7r, 8s, 9s, 13z, 16s)-16-(2-aminométhylbenzothiazol-5-yl)-4,8-dihydroxy-5,5,7,9,13-pentaméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s, 3s, 7s, 10r, 11s, 12s, 16r)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-3-(2-méthylbenzothiazol-5-yl)-4,17-dioxabicyclo[14,1,0]heptadécane-5,9-dione ; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-(2-hydroxyméthylbenzothiazol-5-yl)-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]heptadécane-5,9-dione ; (1s,3s,7s,10r,11s,12s,16r)-3-(2-aminométhylbenzothiazol-5-yl)-7,11-dihydroxy-8,8,10,12,16-pentaméthyl-4,17-dioxabicyclo[14,1,0]heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-16-(2-méthylbenzothiazol-5-yl)-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxyméthylbenzothiazol-5-yl)-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s)-16-(2-aminométhylbenzothiazol-5-yl)-4,8-dihydroxy-7-éthyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-3-(2-méthylbenzothiazol-5-yl)-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-(2-hydroxyméthylbenzothiazol-5-yl)-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s,7s,10r,11s,12s,16r)-3-(2-aminométhylbenzothiazol-5-yl)-7,11-dihydroxy-10-éthyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-7-propyl-5,5,9,13-tétraméthyl-16-(2-méthylbenzothiazol-5-yl)-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxyméthylbenzothiazol-5-yl)-7-propyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s)-16-(2-aminométhylbenzothiazol-5-yl)-4,8-dihydroxy-7-propyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-10-propyl-8,8,12,16-tétraméthyl-3-(2-méthylbenzothiazol-5-yl)-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-(2-hydroxyméthylbenzothiazol-5-yl)-10-propyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s,7s,10r,11s,12s,16r)-3-(2-aminométhylbenzothiazol-5-yl)-7,11-dihydroxy-10-propyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-7-butyl-5,5,9,13-tétraméthyl-16-(2-méthylbenzothiazol-5-yl)-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxyméthylbenzothiazol-5-yl)-7-butyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s)-16-(2-aminométhylbenzothiazol-5-yl)-4,8-dihydroxy-7-butyl-5,5,9,13-tétraméthyl-oxacyclohexadéc-13-ène-2,6-dione ; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-10-butyl-8,8,12,16-tétraméthyl-3-(2-méthylbenzothiazol-5-yl)-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (15,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-(2-hydroxyméthylbenzothiazol-5-yl)-10-butyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (1s,3s,7s,10r,11s,12s,16r)-3-(2-aminométhylbenzothiazol-5-yl)-7,11-dihydroxy-10-butyl-8,8,12,16-tétraméthyl-4,17-dioxabicyclo[14,1,0]-heptadécane-5,9-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-7-allyl-5,5,9,13-tétraméthyl-16-(2-méthylbenzothiazol-5-yl)-oxacyclohexadéc-13-ène-2,6-dione ; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hy
effektor-konjugat gemäss anspruch 1 oder 2, wobei der effektor-grundkörper ausgewählt ist aus der gruppe bestehend aus: (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-thiazol-4-yl)-1-methyl-vinyl]-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-16-[2-(2-aminomethyl-thiazol-4-yl)-1-methyl-vinyl]-4,8-dihydroxy-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-1-methyl-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-thiazol-4-yl)-1-methyl-vinyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-thiazol-4-yl)-1-methyl-vinyl]-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (45,7r,85,95,13z,165(e))-16-[2-(2-aminomethyl-thiazol-4-yl)-1-methyl-vinyl]-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1 s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-1-methyl-vinyl]-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-thiazol-4-yl)-1-methyl-vinyl]-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-fluor-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-thiazol-4-yl)-1-fluor-vinyl]-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z, 16s(z))-16-[2-(2-aminomethyl-thiazol-4-yl)-1-fluor-vinyl]-4,8-dihydroxy-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(z),7s, 10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-fluor-2-(2-methyl-thiazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-1-fluor-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-thiazol-4-yl)-1-fluor-vinyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-chlor-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s, 13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-thiazol-4-y1)-1-chlor-vinyl]-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminomethyl-thiazol-4-yl)-1-chlor-vinyl]-4,8-dihydroxy-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-chlor-2-(2-methyl-thiazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1 s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-1-chlor-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-3-(2-(2-aminomethyl-thiazol-4-yl)-1-chlor-vinyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[1-fluor-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s, 13z, 16s(z))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-thiazol-4-yl)-1-fluor-vinyl]-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminomethyl-thiazol-4-yl)-1-fluor-vinyl]-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[1-fluor-2-(2-methyl-thiazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-1-fluor-vinyl]-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1 s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-thiazol-4-yl)-1-fluor-vinyl]-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[1-chlor-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-thiazol-4-yl)-1-chlor-vinyl]-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminomethyl-thiazol-4-yl)-1-chlor-vinyl]-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1 s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[1-chlor-2-(2-methyl-thiazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion-, (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-1-chlor-vinyl]-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s, 16r)-3-[2-(2-aminomethyl-thiazol-4-yl)-1-chlor-vinyl]-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-pyridyl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-pyridyl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[1-methyl-2-(2-pyridyl)-vinyl]-oxacyctohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[1-methyl-2-(2-pyridyl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-fluor-2-(2-pyridyl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-fluor-2-(2-pyridyl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-chlor-2-(2-pyridyl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-chlor-2-(2-pyridyl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[1-fluor-2-(2-pyridyl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (1s,3s(z),7s,10r,11s,125,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[1-fluor-2-(2-pyridyl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,95,13z,16s(z))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[1-chlor-2-(2-pyridyl)-vinyl]-oxacyclohexadec-1 3-en-2,6-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[1-chlor-2-(2-pyridyl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-methyl-oxazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-oxazol-4-yl)-1-methyl-vinyl]-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-16-[2-(2-aminomethyl-oxazol-4-yl)-1-methyl-vinyl]-4,8-dihydroxy-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12, 16-pentamethyl-3-[1-methyl-2-(2-methyl-oxazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-oxazol-4-yl)-1-methyl-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,1 0r,11s,125,16r)-3-[2-(2-aminomethyl-oxazol-4-yl)-1-methyl-vinyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[1-methyl-2-(2-methyl-oxazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-oxazol-4-yl)-1-methyl-vinyl]-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-16-[2-(2-aminomethyl-oxazol-4-yl)-1-methyl-vinyl]-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s, 12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[1-methyl-2-(2-methyl-oxazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-oxazol-4-yl)-1-methyl-vinyl]-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-oxazol-4-yl)-1-methyl-vinyl]-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-fluor-2-(2-methyl-oxazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-oxazol-4-yl)-1-fluor-vinyl]-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminomethyl-oxazol-4-yl)-1-fluor-vinyl]-4,8-dihydroxy-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-fluor-2-(2-methyl-oxazol-4-yl)-vinyl]-4,17-dioxa-bicycio[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-oxazol-4-yl)-1-fluor-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-oxazol-4-yl)-1-fluor-vinyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxa-bicycto[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-chlor-2-(2-methyl-oxazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-oxazol-4-yl)-1-chlor-vinyl]-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminomethyl-oxazol-4-yl)-1-chlor-vinyl]-4,8-dihydroxy-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-chlor-2-(2-methyl-oxazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-oxazol-4-yl)-1-chlor-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-oxazol-4-yl)-1-chlor-vinyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[1-fluor-2-(2-methyl-oxazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s, 13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-oxazol-4-yl)-1-fluor-vinyl]-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s, 13z,165(z))-16-[2-(2-aminomethyl-oxazol-4-yl)-1-fluor-vinyl]-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[1-fluor-2-(2-methyl-oxazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-oxazol-4-yl)-1-fluor-vinyl]-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1 s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-oxazol-4-yl)-1-fluor-vinyl]-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[1-chlor-2-(2-methyl-oxazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-oxazol-4-yl)-1-chlor-vinyl]-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(z))-16-[2-(2-aminomethyl-oxazol-4-yl)-1-chlor-vinyl]-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[1-chlor-2-(2-methyl-oxazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-oxazol-4-yl)-1-chlor-vinyl]-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(z),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-oxazol-4-yl)-1-chlor-vinyl]-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-1 3-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-thiazol-4-yl)-vinyl]-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-16-[2-(2-aminomethyl-thiazol-4-yl)-vinyl]-4,8-dihydroxy-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[2-(2-methyl-thiazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-thiazol-4-yl)-vinyl]-7,11 -dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-16-[2-(2-hydroxymethyl-thiazol-4-yl)-vinyl]-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s(e))-16-[2-(2-aminomethyl-thiazol-4-yl)-vinyl]-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[2-(2-methyl-thiazol-4-yl)-vinyl]-4,17 -dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e), 7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-vinyl]-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s(e),7s,10r,11s,12s,16r)-3-[2-(2-aminomethyl-thiazol-4-yl)-vinyl]-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s(e))-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[2-(2-pyridyl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[2-(2-pyridyl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s.7r.8s.9s, 13z, 16s(e))-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-[2-(2-pyridyl)-vinyl]-oxacyclohexadec-13-en-2,6-dion; (1s,3s(e),7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-[2-(2-pyridyl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-(2-methyl-benzothiazol-5-yl)-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxymethyl-benzothiazol-5-yl)-5,5,7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-16-(2-aminomethyl-benzothiazol-5-yl)-4,8-dihydroxy-5, 5, 7,9,13-pentamethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(2-methyl-benzothiazol-5-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-(2-hydroxymethyl-benzothiazol-5-yl)-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-3-(2-aminomethyl-benzothiazol-5-yl)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxymethyl-benzothiazol-5-yl)-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s, 13z, 16s)-16-(2-aminomethyl-benzothiazol-5-yl)-4,8-dihydroxy-7-ethyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-3-(2-methyl-benzothiazol-5-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-(2-hydroxymethyl-benzothiazol-5-yl)-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-3-(2-aminomethyl-benzothiazol-5-yl)-7,11-dihydroxy-10-ethyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-7-propyl-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxymethyl-benzothiazol-5-yl)-7-propyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-16-(2-aminomethyl-benzothiazol-5-yl)-4,8-dihydroxy-7-propyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-10-propyl-8,8,12,16-tetramethyl-3-(2-methyl-benzothiazol-5-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-(2-hydroxymethyl-benzothiazol-5-yl)-10-propyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-3-(2-aminomethyl-benzothiazol-5-yl)-7,11-dihydroxy-10-propyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-7-butyl-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxymethyl-benzothiazol-5-yl)-7-butyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-16-(2-aminomethyl-benzothiazol-5-yl)-4,8-dihydroxy-7-butyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-10-butyl-8,8,12,16-tetramethyl-3-(2-methyl-benzothiazol-5-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-(2-hydroxymethyl-benzothiazol-5-yl)-10-butyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-3-(2-aminomethyl-benzothiazol-5-yl)-7,11-dihydroxy-10-butyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-7-allyl-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxymethyl-benzothiazol-5-yl)-7-allyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-16-(2-aminomethyl-benzothiazol-5-yl)-4,8-dihydroxy-7-allyl-5,5,9,13-tetramethyl-oxacyclohexadec-13-en-2,6-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-10-allyl-8,8,12,16-tetramethyl-3-(2-methyl-benzothiazol-5-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-(2-hydroxymethyl-benzothiazol-5-yl)-10-allyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.o]heptadecan-5,9-dion; (1s,3s,7s,10r,11s,12s,16r)-3-(2-aminomethyl-benzothiazol-5-yl)-7,11-dihydroxy-10-allyl-8,8,12,16-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-7-prop-2-inyl-5, 5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-oxacyclohexadec-13-en-2,6-dion; (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-16-(2-hydroxymethyl-benzothiazol-5-yl)-7-prop-2-inyl-5,5,9,13-tetramethyl-oxacyc