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pemetrexed har vist sig at være clastogent hos mus i in vivo mikronukleustesten.
pemetrexed has been shown to be clastogenic in the in vivo micronucleus test in the mouse.

dasatinib var clastogent in vitro med deling af ovarieceller fra kinesisk hamster.
dasatinib was clastogenic in vitro to dividing chinese hamster ovary cells.

cabozantinib har ikke udvist noget mutagent eller clastogent potentiale i et standardbatteri af genotoksicitetsbestemmelser.
cabozantinib has shown no mutagenic or clastogenic potential in a standard battery of genotoxicity assays.

entecavir var clastogent over for humane lymfocytkulturer ved koncentrationer, der var betragteligt større end de kliniske.
entecavir was clastogenic to human lymphocyte cultures at concentrations substantially higher than those achieved clinically.

dasatinib var clastogent in vitro med deling af cho-celler (chinese hamster ovary celler).
dasatinib was clastogenic in vitro to dividing chinese hamster ovary (cho) cells.

olanzapin var ikke mutagent eller clastogent i en række standardtests, der omfattede bakterielle mutationstests og in vitro og in vivo tests med oral administration hos pattedyr.
olanzapine was not mutagenic or clastogenic in a full range of standard tests, which included bacterial mutation tests and in vitro and oral in vivo mammalian tests.

mutagenicitet olanzapin var ikke mutagent eller clastogent i en række standardtests, der omfattede bakterielle mutationstests og in vitro og in vivo tests med oral administration hos pattedyr.
97 mutagenicity olanzapine was not mutagenic or clastogenic in a full range of standard tests, which included bacterial mutation tests and in vitro and oral in vivo mammalian tests.

5. 3 prækliniske sikkerhedsdata 99m tc- depreotid var ikke mutagent in vitro i ames test eller i muselymfom test, og det var ikke clastogent in vivo i muse micronucleus testen.
5.3 preclinical safety data 99m tc-depreotide was not mutagenic in vitro in the ames test or mouse lymphoma test, and it was not clastogenic in vivo in the mouse micronucleus test.

hvis der er indikationer af dannelse af mikrokerner i et in vitro-mikrokerneassay, skal der udføres yderligere testning med brug af passende farvningsprocedurer for at påvise et eventuelt aneugent eller clastogent respons.
if there are indications of micronucleus formation in an in vitro micronucleus assay further testing with appropriate staining procedures shall be conducted to clarify if there is an aneugenic or clastogenic response.

det var ikke clastogent i en in vitro test med humane lymfocytter (ingen induktion af strukturel kromosomaberration, men øgede antallet af polyploide celler) og inducerede en stigning i antallet af mikronuklei i in vivo test hos rotter.
it was not clastogenic in an in vitro test in human lymphocytes (no induction of structural chromosomal aberration but it increased number of polyploid cells) and induced an increase of micronuclei in the in vivo test in rats.

i tilfælde af et positivt resultat af in vivo-mikrokerneassayet skal der anvendes en passende farvningsprocedure såsom fluorescens-in situ-hybridisering (fish) til påvisning af et aneugent og/eller clastogent respons.
in case of positive result in the in vivo micronucleus assay, appropriate staining procedure such as fluorescence in-situ hybridisation (fish) shall be used to identify an aneugenic and/or clastogenic response.