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plasma-cortisol
cortisol

binyreinsufficiens kan kræve livslang behandling for at erstatte det manglende cortisol.
adrenal insufficiency can require life-long treatment to replace the missing cortisol.

hydrocortison erstatter den naturlige cortisol, der mangler hos patienter med binyreinsufficiens.
hydrocortisone replaces the natural cortisol that is missing in patients with adrenal insufficiency.

denne terminale halveringstid ligner farmakokinetikken af endogent cortisol, der også er sekretionsstyret.
this terminal half-life is similar to the pharmacokinetics of endogenous cortisol that also is secretion-controlled.

forskerne be mærkede, at elektriske felter kan for øge kroppens produktion af cortisol og tpa.
the researchers did no tice that electrical fields might increase the body's production of cortisole and tpa.

dette medførte en større reduktion af plasma-cortisol sammenlignet med fluticasonpropionat alene.
this resulted in a greater reduction of plasma cortisol as compared with fluticasone propionate alone.

binyrebarkinsufficiens optræder, når binyrerne (lige over nyrerne) ikke producerer nok af hormonet cortisol.
adrenal insufficiency occurs when your adrenal glands (just above your kidneys) do not produce enough of the hormone cortisol.

cortisol er bundet i plasma til kortikosteroidbindende globulin (cbg – også kaldet transcortin) og albumin.
in plasma, cortisol is bound to corticosteroid-binding globulin (cbg, also called transcortin) and albumin.

hos laboratoriedyr elimineres hydrocortisonaceponat ad samme rute som hydrocortison (et andet navn for endogen cortisol) via urin og faeces.
in laboratory animals, hydrocortisone aceponate is eliminated the same way as hydrocortisone (other name for endogenous cortisol) through urine and faeces.

en enkelt dosis af albiglutid på 50 mg nedsatte ikke den modregulerende hormonrespons på hypoglykæmi af glucagon, adrenalin, noradrenalin, cortisol eller væksthormon.
a single dose of albiglutide 50 mg did not impair the glucagon, epinephrine, norepinephrine, cortisol or growth hormone counter-regulatory hormone response to hypoglycaemia.

dette nødvendiggør ikke en krisehandling, da den adrenale funktion generhverves i løbet af få dage, hvilket kan verificeres ved måling af plasma-cortisol.
this does not need emergency action as adrenal function is recovered in a few days, as verified by plasma cortisol measurements.

tolerancestudier med 3 og 5 gange den anbefalede dosis i dobbelt så lang tid som den anbefalede varighed af behandlingen resulterede i en reversibel kapacitet for produktion af cortisol, som normaliseredes 7 til 9 uger efter behandlingen.
tolerance studies using 3 and 5 times the recommended dosage for twice the recommended duration of treatment resulted in a reduced capacity for production of cortisol that is fully reversible within 7 to 9 weeks after the end of treatment.

da mitotan øger plasmaniveauet af steroidbindende proteiner, er bestemmelser af frit cortisol og acth nødvendige for optimal dosering af steroidsubstitution (se pkt.4. 4) .
since mitotane increases plasma level of steroid binding proteins, free cortisol and acth determinations are necessary for optimal dosing of steroid substitution (see section 4.4) .

hos hunde, der blev behandlet med den terapeutiske dosis i ti sammenhængende dage, faldt niveauet af serum-cortisol fra dag fem og derefter og vendte tilbage til normale værdier indenfor ti dage efter endt behandling.
in dogs treated at the therapeutic dose for ten consecutive days, serum cortisol levels decreased from five days onward and returned to normal values within ten days after the end of treatment.

en lille mængde cortisol udskilles uændret i urinen (<0,5 % af den daglige produktion), hvilket betyder, at cortisol elimineres fuldstændigt ved metabolisme.
a small amount of cortisol is excreted in the urine unchanged (<0.5% of the daily production), meaning that cortisol is eliminated completely by metabolism.

da mitotan øger plasmaniveauerne for steroidbindende proteiner, er bestemmelse af frit cortisol og corticotropin (acth) nødvendige for optimal dosering af steroidsubstitution (se pkt.4. 8) .
since mitotane increases plasma levels of steroid binding proteins, free cortisol and corticotropin (acth) determinations are necessary for optimal dosing of steroid substitution (see section 4.8) .