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emtricitabin fosforyleres af celleenzymer til at danne emtricitabintriphosphat.
emtricitabine is phosphorylated by cellular enzymes to form emtricitabine triphosphate.

emtricitabin fosforyleres af celleenzymer, hvorved der dannes emtricitabintriphosphat.
emtricitabine is phosphorylated by cellular enzymes to form emtricitabine triphosphate.

intracellulært tenofovir fosforyleres dernæst til den aktive metabolit tenofovirdiphosphat.
intracellular tenofovir is subsequently phosphorylated to the active metabolite tenofovir diphosphate.

intracellulært tenofovir fosforyleres dernæst til den farmakologisk aktive metabolit tenofovirdiphosphat.
intracellular tenofovir is subsequently phosphorylated to the pharmacologically active metabolite tenofovir diphosphate.

emtricitabin og tenofovir fosforyleres af celleenzymer til at danne henholdsvis emtricitabintriphosphat og tenofovirdiphosphat.
emtricitabine and tenofovir are phosphorylated by cellular enzymes to form emtricitabine triphosphate and tenofovir diphosphate, respectively.

det fosforyleres effektivt af cellulære kinaser til den aktive trifosfatform, som har en intracellulær halveringstid på 14 timer.
it is efficiently phosphorylated by cellular kinases to the active triphosphate form, which has an intracellular half-life of 14 hours.

undersøgelser in vitro har vist, at både emtricitabin og tenofovir kan fosforyleres fuldstændigt, når de kombineres i celler.
in vitro studies have shown that both emtricitabine and tenofovir can be fully phosphorylated when combined together in cells.

det fosforyleres ved cellulære kinaser til stavudin trifosfat, som hæmmer hiv revers transkriptase ved at konkurrere med det naturlige substrat thymidin trifosfat.
it is phosphorylated by cellular kinases to stavudine triphosphate which inhibits hiv reverse transcriptase by competing with the natural substrate, thymidine triphosphate.

in vivo hydrolyseres tenofoviralafenamid i cellerne til at danne tenofovir (primær metabolit), som fosforyleres til den aktive metabolit tenofovirdiphosphat.
in vivo, tenofovir alafenamide is hydrolysed within cells to form tenofovir (major metabolite), which is phosphorylated to the active metabolite tenofovir diphosphate.

in vivo hydrolyseres tenofoviralafenamid i cellerne, hvorved der dannes tenofovir (primær metabolit), som fosforyleres til den aktive metabolit tenofovirdiphosphat.
in vivo, tenofovir alafenamide is hydrolysed within cells to form tenofovir (major metabolite), which is phosphorylated to the active metabolite tenofovir diphosphate.

zidovudin og stavudin fosforyleres ved det cellulære enzym (thymidin kinase), som fortrinsvis fosforylerer zidovudin og dermed øger fosforyleringen af stavudin til dets aktive trifosfat form.
zidovudine and stavudine are phosphorylated by the cellular enzyme (thymidine kinase), which preferentially phosphorylates zidovudine, thereby decreasing the phosphorylation of stavudine to its active triphosphate form.

emtricitabin fosforyleres af celleenzymer til at danne emtricitabin 5 '- trifosfat, som kompetitivt hæmmer hiv- 1 reverse transkriptase, som resulterer i dna- kædeterminering.
emtricitabine is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate, which competitively inhibits hiv-1 reverse transcriptase, resulting in dna chain termination.

farmakologisk øger ribavirin fosforylerede metabolitter af purinnukleosider in vitro.
pharmacologically, ribavirin increases phosphorylated metabolites of purine nucleosides in vitro.