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lipodystrophia:
lipodystrophy:
Laatste Update: 2012-04-11
Gebruiksfrequentie: 4
Kwaliteit:
tenofovir er strukturelt relateret til nukleosidanaloger, og derfor kan risikoen for lipodystrophia ikke udelukkes.
tenofovir is structurally related to nucleoside analogues hence the risk of lipodystrophy cannot be excluded.
antiretroviral kombinationsbehandling er blevet forbundet med omfordeling af legemsfedt (lipodystrophia) hos hiv- patienter.
combination antiretroviral therapy has been associated with the redistribution of body fat (lipodystrophy) in hiv patients.
hos hiv- inficerede patienter er antiretroviral kombinationsbehandling blevet forbundet med omfordeling af legemsfedt (lipodystrophia).
in hiv infected patients, combination antiretroviral therapy has been associated with the redistribution of body fat (lipodystrophy).
144-ugers kliniske data fra antiretroviral-naive patienter tyder imidlertid på, at risikoen for lipodystrophia var lavere med tenofovirdisoproxilfumarat end med stavudin ved indgivelse sammen med lamivudin og efavirenz.
however, 144-week clinical data from antiretroviral-naïve patients indicate that the risk of lipodystrophy was lower with tenofovir disoproxil fumarate than with stavudine when administered with lamivudine and efavirenz.
en højere risiko for lipodystrophia er blevet forbundet med individuelle faktorer som f. eks. højere alder, og med lægemiddelrelaterede faktorer som f. eks. længere varighed af antiretroviral behandling og associeret metaboliske forstyrrelser.
a higher risk of lipodystrophy has been associated with individual factors such as older age, and with drug related factors such as longer duration of antiretroviral treatment and associated metabolic disturbances.
10 antiretroviral kombinationsbehandling er hos hiv- patienter associeret med omfordeling af kropsfedt (lipodystrophia) herunder tab af subkutant fedt perifert og i ansigtet, øget intraabdominalt og visceralt fedt, brysthypertrofi og dorsocervical fedtophobning ("buffalo hump").
combination antiretroviral therapy has been associated with redistribution of body fat (lipodystrophy) in hiv patients including the loss of peripheral and facial subcutaneous fat, increased intra-abdominal and visceral fat, breast hypertrophy and dorsocervical fat accumulation (buffalo hump).
