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pk/ pd- modellering.
the aim of this study is to investigate: bortezomib pk after single and multiple dose treatment; the mechanisms behind the observed changes in the pk parameters after repeated dosing; any clinically plausible intrinsic factors that may explain and reduce variability; the relationship between body weight/ body surface area/ lean body weight) and pk parameters since dosing regimen is based on bsa; the concentration-proteasome inhibition relationship using pk/ pd-modelling;