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daten einer " steady state"-studie mit gesunden probanden deuten auf eine tagesrhythmische schwankung in der pharmakokinetik von indinavir hin.
data from a steady state study in healthy volunteers indicate that there is a diurnal variation in the pharmacokinetics of indinavir.following a dosage regimen of 800 mg every 8 hours, measured peak plasma concentrations (cmax) after morning, afternoon and evening doses were 15,550 nm, 8,720 nm and 8,880 nm, respectively.