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further hydroxylation occurs prior to elimination.
yderligere hydroxylering forekommer før elimination.

biotransformations in the cat occur by hydroxylation in the liver.
biotransformationer i katte sker ved hydroxylering i leveren.

doxazosin is primarily metabolised by o-demethylation and hydroxylation.
metaboliseringen af doxazosin sker primært ved o- demetylation og hydroxylation.

sirolimus is extensively metabolised by o-demethylation and/ or hydroxylation.
sirolimus metaboliseres i vid udstrækning af o- demethylation og/ eller hydroxylation.

celecoxib is metabolised in the liver by hydroxylation, oxidation and some glucuronidation.
30 celecoxib metaboliseres i leveren ved hydroxylering, oxidation og til dels glucuronidation.

pioglitazone undergoes extensive hepatic metabolism by hydroxylation of aliphatic methylene groups.
pioglitazon gennemgår en omfattende metabolisme i leveren ved hydroxylering af alifatiske methylengrupper.

metabolism pioglitazone undergoes extensive hepatic metabolism by hydroxylation of aliphatic methylene groups.
metabolisme pioglitazon gennemgår en omfattende metabolisme i leveren ved hydroxylering af alifatiske methylengrupper.

cholecalciferol is converted in the liver by hydroxylation to the active form 25- hydroxycholecalciferol.
cholecalciferol omdannes i leveren ved hydroxylering til den aktive form 25 - hydroxycholecalciferol.

the predominant metabolic pathways of excreted radioactivity are hydroxylation with subsequent glucuronidation, or hydrolysis.
de primære metaboliseringsveje for udskillelse af radioaktivitet er hydroxylering med efterfølgende glukuronidering, eller hydrolyse.

the major metabolic pathway is deboronation to form two deboronated metabolites that subsequently undergo hydroxylation to several metabolites.
den primære metabolisme er deborering, hvorved der dannes to deborerede metabolitter, som efterfølgende undergår hydroksylering til flere metabolitter.

a second disposition pathway involves hydroxylation mediated by cyp2c19 (see section 5.2).
en anden udskillelsesvej omfatter hydroxylering medieret af cyp2c19 (se pkt.

subsequently, amfenac undergoes extensive metabolism to more polar metabolites involving hydroxylation of the aromatic ring leading to glucuronide conjugate formation.
derefter gennemgår amfenac en omfattende metabolisme til mere polære metabolitter, der involverer hydroxylering af den aromatiske ring, som fører til dannelse af glukuronidkonjugat.

aripiprazole is extensively metabolised by the liver primarily by three biotransformation pathways: dehydrogenation, hydroxylation, and n-dealkylation.
aripiprazol metaboliseres hovedsageligt i leveren via tre biotransformationsveje: dehydrogenering, hydroxylering og n-dealkylering.

biotransformation:doxazosin is extensively metabolised with 5% excreted as unchanged product.doxazosin is primarily metabolised by o-demethylation and hydroxylation.
fordelingsvolumen:1 liter/kg.biotransformation:doxazosin bliver omfattende metaboliseret med 5% udskilt som uændret produkt doxazosin bliver primært metaboliseret ved o-demethylering og hydroxylering.

during in vitro temsirolimus metabolism studies, sirolimus, seco-temsirolimus and seco-sirolimus were observed; additional metabolic pathways were hydroxylation, reduction and demethylation.
ved in vitro studier af temsirolimus-metabolismen blev der observeret sirolimus, seco-temsirolimus og seco-sirolimus.ekstra metaboliske veje var hydroxylering, reduktion og demethylering.