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the thioguanine nucleotides are also incorporated into nucleic acids and this contributes to the cytotoxic effects of the active substance.
thioguanin-nukleotiderne er også inkorporeret i nukleinsyrer, hvilket er medvirkende til det aktive stofs cytotoksiske virkning.
6–mercaptopurine is an inactive pro-drug which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides for cytotoxicity.
6–mercaptopurin er et inaktivt pro-drug, som virker som en purinantagonist, men kræver celleoptagelse og intracellulær anabolisme over for thioguaninnukleotider for cytotoksicitet.
many cytotoxic medicinal products direct or indirect dna synthesis inhibitors lead to macrocytosis (hydroxycarbamide, cytarabine, mecaptopurine, thioguanine) .
mange cytotoksiske lægemidler direkte eller indirekte dna-syntesehæmmere medfører makrocytose (hydroxycarbamid, cytarabin, mercaptopurin, thioguanin) .
many cytotoxic medicinal products – direct or indirect dna synthesis inhibitors – lead to macrocytosis (hydroxycarbamide, cytarabine, mecaptopurine, thioguanine).
mange cytotoksiske lægemidler – direkte eller indirekte dna- syntesehæmmere – medfører makrocytose (hydroxycarbamid, cytarabin, mercaptopurin, thioguanin).
the intracellular anabolism of 6-merpactopurine is catalysed by several enzymes to eventually form 6-thioguanine nucleotides (tgns), but a variety of intermediary tgns are formed en route to the tgns.
6-merpactopurins intracellulære anabolisme katalyseres af flere enzymer til dannelse af 6-thioguanin-nukleotider (tgn’er), men der dannes flere forskellige midlertidige tgn’er i processen mod tgn’er.