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irinotecan is metabolized by carboxylesterase to sn-38.
umbrot írínótekans í sn-38 fara fram fyrir tilstilli karboxýlesterasa.
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:
the metabolic conversion of irinotecan to the active metabolite sn-38 is mediated by carboxylesterase enzymes.
umbrot írínótekans í virka umbrotsefnið sn-38 fara fram fyrir tilstilli karboxýlesterasaensíma.
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:
selexipag is hydrolysed to its active metabolite by hepatic carboxylesterase 1 (ces1; see section 5.2).
selexipag er vatnsrofið í virka umbrotsefnið fyrir tilstilli lifrarkarboxýlesterasa 1 (ces1, sjá kafla 5.2).
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:
intracellular hydrolytic prodrug cleavage catalysed by enzymes including carboxylesterase 1 and sequential phosphorylation steps catalysed by nucleotide kinases result in formation of the pharmacologically active uridine nucleoside analogue triphosphate.
klofnun forlyfs innan frumna með vatnsrofi sem hvatast með ensímum, meðal annars karboxýlesterasa 1 og raðfosfórýleringarskrefum sem hvatast með núkleótíðkínösum, veldur myndun lyfjafræðilega virks úridín núkleósíðlíks þrífosfats.
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:
in vitro, n-desmethyl enzalutamide is metabolized to the carboxylic acid metabolite by carboxylesterase 1, which also plays a minor role in the metabolism of enzalutamide to the carboxylic acid metabolite.
n-desmetyl enzalutamid umbrotnar in vitro í karboxýlsýruafleiðuna fyrir tilstilli carboxylesterasa 1, sem hefur einnig minni háttar hlutverki að gegna við umbrot enzalutamids yfir í karboxýlsýruafleiðuna.
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:
edoxaban is metabolised via hydrolysis (mediated by carboxylesterase 1), conjugation or oxidation by cyp3a4/5 (< 10%).
edoxaban umbrotnar með vatnsrofi (sem miðlað er af karboxýlesterasa 1), samtengingu eða oxun fyrir tilstilli cyp3a4/5 (< 10%).
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:
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capecitabine is first metabolised by hepatic carboxylesterase to 5'-dfcr, which is then converted to 5'-dfur by cytidine deaminase, principally located in the liver and tumour tissues.
fyrst er capecítabín umbrotið af lifrar karboxýlesterasa í 5’-dfcr, sem er síðan breytt í 5’- dfur af cýtidín deamínasa, aðallega staðsett í lifur og æxlisvef.
Laatste Update: 2017-04-26
Gebruiksfrequentie: 2
Kwaliteit:
the deacetylation is mediated by carboxyl- esterases (i.e. carboxylesterase 1b/c and 2) and may also be mediated by other hydrolytic enzymes.
acetýlsviptingin er fyrir tilstilli karboxýlesterasa (þ.e. karboxýlesterasa 1b/c og 2) og getur einnig verið fyrir tilstilli annarra vatnsrjúfandi ensíma.
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit:
amidase present in blood, plasma, serum, simulated gastric fluid and simulated intestinal fluid as well as human carboxylesterases hce-1 and hce-2 are not responsible for the biotransformation of safinamide to nw-1153.
amíðasi í blóði, plasma, sermi, hermimagavökva og hermiþarmavökva sem og mennsku carboxylesterase hce-1 og hce-2 eru ekki ábyrg fyrir umbrotum á safinamíði til nw-1153.
Laatste Update: 2017-04-26
Gebruiksfrequentie: 1
Kwaliteit: