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inhibition of cyp isoforms
inibizzjoni ta’ isoformi ta’ cyp

cyp isoforms selective substrates:
substrati selettivi ta ’ isoformi ta ’ cyp:

two isoforms, cox-1 and cox-2, have been identified.
Ġew identifikati żewġ iżoforom, cox-1 u cox-2.

there are two isoforms of cox, cox-1, and cox-2.
hemm żewg isoforms ta ’ cox, cox- 1 u cox- 2.

rivaroxaban neither inhibits nor induces any major cyp isoforms like cyp3a4.
rivaroxaban la jinibixxi u lanqas jindotta isoformi maġġuri ta’ cyp bħal cyp3a4.

it binds with high affinity to the vegf-a isoforms (e.g.
teħel b’affinità kbira ma’ l-iżoformi vegf-a (e.ż.

the cyclo-oxygenase enzyme (cox) is present in two isoforms.
l-enzima cyclo-oxygenase (cox) hija preżenti f’żewġ isoformi.

interaction with substrates of cyp 450 isoforms are thus not expected and have not been shown.
għalhekk, interazzjoni ma’ sottostrati ta’ iżoformi ta’ cyp 450 mhumiex mistennija u ma ġewx osservati.

cyp2d15 and cyp3a12 were identified as the canine isoforms involved in the hepatic biotransformation of maropitant.
cyp2d15 u cyp3a12 kienu identifikati bħala l- forom fil - klieb involuti fil- biotrasformazzjoni ta ’ maropitant fil- fwied.

based on in vitro studies, empagliflozin does not inhibit, inactivate, or induce cyp450 isoforms.
mill-istudji in vitro, empagliflozin ma jimpedixxix, jinattivax, jew jinduċi isoformi ta' cyp450.

cyp1a and cyp3a-related enzymes were identified as the feline isoforms involved in the hepatic biotransformation of maropitant.
cyp2d15 u cyp3a12 kienu identifikati bħala l-forom fil-qtates involuti fil- bijotrasformazzjoni ta’ maropitant fil-fwied.

it is unlikely that atosiban inhibits hepatic cytochrome p450 isoforms in humans (see section 4.5).
ma jidhirx li l- atosiban iwaqqaf l- effett ta ’ l- isoforomi ta ’ cytochrome p450 tal- fwied (ara sezzjoni 4. 5 prodotti mediċinali oħra li ma jaqblux ma ’ dan il- prodott u affarjiet oħra li jistgħu jibdlu l- effett farmaċewtiku tal- prodott).

in vitro evaluation indicated that trifluridine and fty had no inductive effect on human cyp isoforms (see section 5.2).
evalwazzjoni in vitro indikat li trifluridine u fty ma kellhomx effett ta’ induzzjoni fuq l-iżoformi cyp tal-bnedmin (ara sezzjoni 5.2).

vardenafil is metabolised predominantly by hepatic enzymes via cytochrome p450 (cyp) isoform 3a4, with some contribution from cyp3a5 and cyp2c isoforms.
vardenafil fil-biċċa l-kbira huwa mmetabolizzat mill-enzimi tal-fwied li jużaw ċitokromju p450 (cyp) isoform 3a4, bi ftit kontribuzzjoni mill-isoformi cyp3a5 u cyp2c.

fentanyl is metabolised in the liver and in the intestinal mucosa to norfentanyl by cyp3a4 isoform.
fentanyl huwa metabolizzat fil-fwied u fil-mukuża tal-musrana għal norfentanyl permezz ta’ isoforma ta’ cyp3a4.