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voriconazole plasma concentrations during coadministration of methadone were comparable to voriconazole levels (historical data) in healthy subjects without any comedication.
frequente controle op ongewenste

of a panel of potential comedications (acetaminophen, aciclovir, allopurinol, amphotericin, cytarabine, erythromycin, fluconazole, hydroxyurea, norfloxacin, penicillin v) only erythromycin (ic50 50 µm) and fluconazole (ic50 118 µm) showed inhibition of imatinib metabolism which could have clinical relevance.
van een reeks van potentiële co-medicaties (paracetamol, aciclovir, allopurinol, amfotericine, cytarabine, erythromycine, fluconazol, hydroxyurea, norfloxacine, penicilline v) toonden alleen erythromycine (ic50 50 µm) en fluconazol (ic50 118 µm) een remming van het metabolisme van imatinib, dat klinische relevantie kan hebben.