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integrilin must not be used to treat patients with: − hypersensitivity to the active substance or to any of the excipients − evidence of gastrointestinal bleeding, gross genitourinary bleeding or other active abnormal bleeding within the previous 30 days of treatment − history of stroke within 30 days or any history of haemorrhagic stroke − known history of intracranial disease (neoplasm, arteriovenous malformation, aneurysm) − major surgery or severe trauma within past 6 weeks − a history of bleeding diathesis − thrombocytopaenia ( 1.2 times control, or international normalized ratio (inr) ≥ 2.0 − severe hypertension (systolic blood pressure > 200 mm hg or diastolic blood pressure > 110 mm hg on antihypertensive therapy) − severe renal impairment (creatinine clearance < 30 ml/min) or dependency on renal dialysis; − clinically significant hepatic impairment − concomitant or planned administration of another parenteral gp iib/iiia inhibitor
Laatste Update: 2011-10-23
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