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Indonesian

ada yang lebih tua dari saya

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Indonesisch

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Indonesisch

kamu lebih muda dari saya

Engels

google transleter

Laatste Update: 2014-12-29
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

masih ada yang ditutupi dari saya

Engels

the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors. the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors.

Laatste Update: 2014-04-24
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

umurnya jauh lebih tua

Engels

so different from our age

Laatste Update: 2020-11-10
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

menawarkan pekerjaan yang lebih baik

Engels

better job offer

Laatste Update: 2023-04-13
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

sekian dari saya

Engels

that's all from me

Laatste Update: 2023-09-13
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

peluk jauh dari saya

Engels

hug away from me

Laatste Update: 2024-04-14
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

cukup sekian penjelasan dari saya

Engels

enough of my explanation

Laatste Update: 2020-08-27
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

di hari raya yg lebih tua harus memberikan uang ke yang lebih muda

Engels

Laatste Update: 2024-04-10
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

sekian dari saya,saya akhiri wassalam

Engels

from the psp b class, here

Laatste Update: 2020-12-10
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

cukup sekian dari saya dan terima kasih

Engels

that's all and thank you

Laatste Update: 2020-11-01
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

apa jawaban dari saya akan selalu mencintaimu selamanya

Engels

apa jawaban dari i will always love you forever

Laatste Update: 2018-05-02
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

saya anak ke 2 dari 2 bersaudara, kaka saya 8 tahun lebih tua dari saya sekarang berusia 28 tahun, kaka saya bekerja sebagai pegawai bank dari tahun 2014

Engels

i am the 2nd child of 2 siblings, my brother is 8 years older than i am now 28 years old, my brother worked as a bank employee from 2014

Laatste Update: 2020-09-17
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

di mulai dari saya bangun sampai saya tidur kembali

Engels

i pray maghrib and isha prayer

Laatste Update: 2023-09-28
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

sekian cerita dari saya dan terimakasih telah mendengarkan cerita saya ini.

Engels

that's my story and thank you for listening to my story.

Laatste Update: 2022-05-11
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

karna bercanda yang berlebihan

Engels

i learned silence from talking a lot

Laatste Update: 2021-10-26
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

sombong sekali anda! sampai tidak sempat membalas pesan singkat dari saya:'(

Engels

arrogant once you! until it didn't get reply short message from me: ' (

Laatste Update: 2018-11-12
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

Indonesisch

kepada bela saya mengundang anda ke acara ulangtahun saya , saya harap anda datang ke acara saya , salam dari saya nanda permata sari

Engels

dear friends, i invite you to my birthday party, i hope you come to my event, greet me nanda gem sari

Laatste Update: 2023-03-16
Gebruiksfrequentie: 1
Kwaliteit:

Referentie: Anoniem

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