Je was op zoek naar: mikrosomām (Lets - Engels)

eksperimentos ar cilvēka aknu mikrosomām in vitro konstatēja, ka darunavīrs metabolizējas galvenokārt oksidācijas ceļā.
in vitro experiments with human liver microsomes (hlms) indicate that darunavir primarily undergoes oxidative metabolism.

in vitro eksperimenti ar cilvēka aknu mikrosomām liecina, ka lopinavīrs tiek metabolizēts galvenokārt oksidatīvā ceļā.
in vitro experiments with human hepatic microsomes indicate that lopinavir primarily undergoes oxidative metabolism.

pētījumos ar cilvēka aknu mikrosomām konstatēja, ka tipranavīrs inhibē cyp 1a2, cyp 2c9, cyp 2c19 un cyp 2d6.
studies in human liver microsomes indicated tipranavir is an inhibitor of cyp 1a2, cyp 2c9, cyp 2c19 and cyp 2d6.

metabolisms: in vitro eksperimenti ar cilvēka aknu mikrosomām liecina, ka lopinavirs tiek metabolizēts galvenokārt oksidatīvā ceļā.
antiviral activity of kaletra in patients failing protease inhibitor therapy: the clinical relevance of reduced in vitro susceptibility to lopinavir has been examined by assessing the virologic response to kaletra therapy, with respect to baseline viral genotype and phenotype, in 56 patients previous failing therapy with multiple protease inhibitors.

inkubēts ar apvienotām cilvēka aknu mikrosomām, tedizolīds bija stabils, kas liecina, ka tedizolīds nav aknu cyp450 enzīmu substrāts.
when incubated with pooled human liver microsomes, tedizolid was stable suggesting that tedizolid is not a substrate for hepatic cyp450 enzymes.

in vitro pētījumu dati, izmantojot cilvēka aknu mikrosomas norāda, ka veidojas neliels daudzums n- demetilēta-topotekāna.
in vitro data using human liver microsomes indicate the formation of small amounts of n- demethylated topotecan.