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huwa antiċipat li tacrolimus ma jkunx dijalisibbli ibbażat fuq piż molekulari għoli, fis-solubbiltà likwida fqir u r’rabta estensiva eritrokita u proteina plażmatika tiegħu.
based on its high molecular weight, poor aqueous solubility, and extensive erythrocyte and plasma protein binding, it is anticipated that tacrolimus will not be dialysable.
tliet individwi kellhom tagħbija virali mhux rilevabbli u wieħed kellu hiv-rna plażmatika ta’ 900 kopja/ml fil-Ġimgħa 48.
three subjects had undetectable viral load and one had plasmatic hiv-rna of 900 copies/ml at week 48.
it- tneħħija tiegħu ssir permezz tal- mukuża intestinali, u fi grad iktar baxx, permezz tat- tneħħija minn ġol- bila, li tirriżulta f’ valuri tat- tneħħija plażmatika ta ’ 1. 7 ml/ min/ kg.
its excretion is carried out through the intestinal mucous and in a lower extent, through bile excretion, resulting in plasmatic clearance values of 1.7 ml/ min/ kg.