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fi studji dwar l-interazzjoni li saru fuq individwi b’saħħithom, prinċipalment bl-użu ta’ disinn ta’ doża waħda, dapagliflozin ma biddilx il-farmakokinetika ta’ pioglitazone, sitagliptin, glimepiride, hydrochlorothiazide, bumetanide, valsartan, digoxin (sostrat ta’ p-gp) jew warfarin (s-warfarin, sostrat ta’ cyp2c9), jew l-effetti antikoagulanti ta’ warfarin kif imkejlin mill-inr.
in interaction studies conducted in healthy subjects, using mainly a single-dose design, dapagliflozin did not alter the pharmacokinetics of pioglitazone, sitagliptin, glimepiride, hydrochlorothiazide, bumetanide, valsartan, digoxin (a p-gp substrate) or warfarin (s-warfarin, a cyp2c9 substrate), or the anti-coagulatory effects of warfarin as measured by inr.