Je was op zoek naar: glykopyrroniumbromid (Noors - Engels)

virkestoff er glykopyrroniumbromid.
the active substance is glycopyrronium bromide.

glykopyrroniumbromid er en muskarinerg reseptorantagonist med høy affinitet.
glycopyrronium bromide is a high affinity muscarinic receptor antagonist.

virkestoffene er indakaterol (som maleat) og glykopyrroniumbromid.
the active substances are indacaterol (as maleate) and glycopyrronium bromide.

nedsatt nyrefunksjon påvirker systemisk eksponering overfor glykopyrroniumbromid.
renal impairment has an impact on the systemic exposure to glycopyrronium bromide.

det er ukjent om glykopyrroniumbromid blir skilt ut i morsmelk hos mennesker.
it is unknown whether glycopyrronium bromide is excreted in human milk.

enurev breezhaler 44 mikrogram inhalasjonspulver, hard kapsel glykopyrronium (glykopyrroniumbromid)
enurev breezhaler 44 micrograms inhalation powder, hard capsules glycopyrronium (glycopyrronium bromide)

in vitro metabolismestudier viste samsvarende metabolske mekanismer for glykopyrroniumbromid mellom dyr og mennesker.
in vitro metabolism studies showed consistent metabolic pathways for glycopyrronium bromide between animals and humans.

hver kapsel inneholder 63 mikrogram av glykopyrroniumbromid (tilsvarende 50 mikrogram glykopyrronium).
each capsule contains 63 micrograms of glycopyrronium bromide (equivalent to 50 micrograms glycopyrronium).

verken glykopyrroniumbromid eller dets metabolitter krysset placentabarrieren signifikant hos drektige mus, kaniner og hunder.
glycopyrronium bromide and its metabolites did not significantly cross the placental barrier of pregnant mice, rabbits and dogs.

hver kapsel inneholder 143 mikrogram indakaterol maleat tilsvarende 110 mikrogram indakaterol og 63 mikrogram glykopyrroniumbromid tilsvarende 50 mikrogram glykopyrronium.
each capsule contains 143 µg of indacaterol maleate equivalent to 110 µg of indacaterol and 63 µg of glycopyrronium bromide equivalent to 50 µg of glycopyrronium.

multinasjonal, registerbasert kohortstudie for å vurdere rmp-spesifiserte sikkerhetsresultater i forbindelse med indakaterol/ glykopyrroniumbromid i europa
multinational database cohort study to assess rmp specified safety outcomes in association with indacaterol/glycopyrronium bromide in europe.

hver avgitte dose (dosen som forlater munnstykket på inhalatoren) inneholder 55 microgram av glykopyrroniumbromid tilsvarende 44 mikrogram av glykopyrronium.
each delivered dose (the dose that leaves the mouthpiece of the inhaler) contains 55 micrograms of glycopyrronium bromide equivalent to 44 micrograms of glycopyrronium.

det var ingen betydelige forskjeller i total systemisk eksponering (auc) mellom japanesiske and kaukasiske personer etter inhalasjon av glykopyrroniumbromid.
there were no major differences in total systemic exposure (auc) between japanese and caucasian subjects following inhalation of glycopyrronium bromide.

in vitro enzyminduksjonsstudier indikerte ingen klinisk relevant induksjon med glykopyrroniumbromid på cytokrom-p450 isoenzymene, eller på ugt1a1 og de andre transportørene mdr1 og mrp2.
in vitro enzyme induction studies did not indicate a clinically relevant induction by glycopyrronium bromide for cytochrome p450 isoenzymes, or for ugt1a1 and the transporters mdr1 and mrp2.

glykopyrroniumbromid (inkludert dets metabolitter) ble utskilt i melk hos diegivende rotter og forekom i 10 ganger høyere konsentrasjon i melken enn i blodet hos hunnen.
glycopyrronium bromide (including its metabolites) was excreted into the milk of lactating rats and reached up to 10-fold higher concentrations in the milk than in the blood of the dam.

hver avgitt dose (dosen som forlater munnstykket på inhalatoren) inneholder 110 mikrogram indakaterol maleat tilsvarende 85 mikrogram indakaterol og 54 mikrogram glykopyrroniumbromid tilsvarende 43 mikrogram glykopyrronium.
each delivered dose (the dose that leaves the mouthpiece of the inhaler) contains 110 µg of indacaterol maleate equivalent to 85 µg of indacaterol and 54 µg of glycopyrronium bromide equivalent to 43 µg of glycopyrronium.

effekten på hjertefrekvens og qtc-intervall ved 150 mikrogram glykopyrroniumbromid (tilsvarende 120 mikrogram glykopyrronium) administrert intravenøst ble undersøkt hos unge, friske personer.
the effect on heart rate and qtc interval of 150 micrograms glycopyrronium bromide (equivalent to 120 micrograms glycopyrronium) administered intravenously was investigated in young healthy subjects.

etter intravenøs administrasjon av [3h]-merket glykopyrroniumbromid hos mennesker, er gjennomsnittlig urinutskillelse av radioaktivitet i løpet av 48 timer relatert til 85 % av dosen.
after intravenous administration of [3h]-labelled glycopyrronium bromide to humans, the mean urinary excretion of radioactivity in 48 hours amounted to 85% of the dose.

hemmings-studier in vitro viste at glykopyrroniumbromid ikke har relevant kapasitet til å hemme cyp1a2, cyp2a6, cyp2c8, cyp2c9, cyp2c19, cyp2d6, cyp2e1 eller cyp3a4/5, efflukstransportørene mdr1, mrp2 eller mxr, opptakstransportørene oct1 eller oct2.
in vitro inhibition studies demonstrated that glycopyrronium bromide has no relevant capacity to inhibit cyp1a2, cyp2a6, cyp2c8, cyp2c9, cyp2c19, cyp2d6, cyp2e1 or cyp3a4/5, the efflux transporters mdr1, mrp2 or mxr, and the uptake transporters oct1 or oct2.