Je was op zoek naar: sulfotransferaze (Sloveens - Engels)

vpliv etorikoksiba na zdravila, ki jih presnavljajo sulfotransferaze
effect of etoricoxib on drugs metabolised by sulfotransferases

etorikoksib zveča koncentracijo etinilestradiola z zaviranjem sulfotransferaze, s čimer zavira presnovo etinilestradiola.
it is thought that etoricoxib increases ethinyl estradiol levels because it inhibits sulfotransferase activity thereby inhibiting ethinyl estradiol metabolism.

etorikoksib je zaviralec aktivnosti človeške sulfotransferaze, zlasti sult1e1, in pokazalo se je, da poveča serumske koncentracije etinilestradiola.
etoricoxib is an inhibitor of human sulfotransferase activity, particularly sult1e1, and has been shown to increase the serum concentrations of ethinyl estradiol.

če se pri preskusih in vitro ali in vivo na različnih vrstah ali v različnih pogojih ugotovijo za strupenost pomembne spremembe presnovnega profila preskusne kemikalije, je morda potrebna opredelitev lastnosti udeleženih encimov (npr. encimi faze i, kot so izoencimi od citokroma p450 odvisnega monooksigenaznega sistema, encimi faze ii, kot so izoencimi sulfotransferaze ali uridin difosfat glukuronozil transferaze. ali kateri koli drugi pomembni encimi).
if toxicologically significant alterations in the metabolic profile of the test chemical are observed through either in vitro or in vivo experiments with different species or conditions, characterisation of the enzyme(s) involved may be needed (e.g. phase i enzymes such as isoenzymes of the cytochrome p450-dependent mono-oxygenase system, phase ii enzymes such as isoenzymes of sulfotransferase or uridine diphosphate glucuronosyl transferase, or any other relevant enzymes).