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emtricitabin og tenofovir fosforyleres af celleenzymer til at danne henholdsvis emtricitabintriphosphat og tenofovirdiphosphat.
emtricitabine and tenofovir are phosphorylated by cellular enzymes to form emtricitabine triphosphate and tenofovir diphosphate, respectively.
tenofovir omdannes derefter af konstitutivt eksprimerede celleenzymer til den aktive metabolit, tenofovirdiphosphat, en obligat kædeblokker.
tenofovir is then converted to the active metabolite, tenofovir diphosphate, an obligate chain terminator, by constitutively expressed cellular enzymes.
tenofovir omdannes så til den aktive metabolit, tenofovirdiphosphat, af konstitutivt eksprimerede celleenzymer via to phosphoryleringsreaktioner i såvel hvilende som aktiverede t-celler.
tenofovir is then converted to the active metabolite, tenofovir diphosphate, by constitutively expressed cellular enzymes through two phosphorylation reactions in both resting and activated t cells.
emtricitabin phosphoryleres af celleenzymer til at danne emtricitabin 5'-triphosphat, som kompetitivt hæmmer hiv 1 reverse transkriptase, som resulterer i dna-kædeterminering.
emtricitabine is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate, which competitively inhibits hiv-1 reverse transcriptase, resulting in dna chain termination.
emtricitabin fosforyleres af celleenzymer til at danne emtricitabin 5 '- trifosfat, som kompetitivt hæmmer hiv- 1 reverse transkriptase, som resulterer i dna- kædeterminering.
emtricitabine is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate, which competitively inhibits hiv-1 reverse transcriptase, resulting in dna chain termination.