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temozolomid sa v tele premieňa na ďalšiu zlúčeninu nazývanú mtic.
in the body, temozolomide is converted to another compound called mtic.

temozolomid sa v tele mení na ďalšiu zlúčeninu, nazývanú mtic.
in the body, temozolomide is converted to another compound called mtic.

temozolomid sa v tele mení na ďalšiu zlúčeninu, ktorá sa nazýva mtic.
in the body, temozolomide is converted to another compound called mtic.

mtic sa viaže na dna buniek počas ich reprodukcie, čo zastavuje delenie buniek.
mtic binds to the dna of cells while they are reproducing, which stops cell division.

mtic sa 7 westferry circus, canary wharf, london e14 4hb, uk tel.
mtic 7 westferry circus, canary wharf, london e14 4hb, uk tel.

in vivo bol t1/2 mtic podobný t1/2 tmz a to 1,8 hod.
in vivo, the t1/2 of mtic was similar to that of tmz, 1.8 hr.

predpokladá sa, že za cytotoxicitu mtic je primárne zodpovedná alkylácia dna, predovšetkým na pozíciách o6 a n7guanínu.
the cytotoxicity of mtic is thought to be primarily due to alkylation of dna mainly at the o6 and n7 positions of guanine.

predpokladá sa, že toxicitu mtic primárne spôsobuje alkylácia guanínu v polohe o6 s dodatočnou alkyláciou prebiehajúcou v polohe n7.
the cytotoxicity of mtic is thought to be due primarily to alkylation at the o6 position of guanine with additional alkylation also occurring at the n7 position.

predpokladá sa, že cytotoxicitu mtic primárne spôsobuje alkylácia na pozícii o6 guanínu, spolu s ďalšou alkyláciou na pozícii n7.
the cytotoxicity of mtic is thought to be due primarily to alkylation at the o6 position of guanine with additional alkylation also occurring at the n7 position.

v závislosti od auc je expozícia mtic ~ 2,4 % a expozícia aic ~ 23 %.
relative to the auc of tmz, the exposure to mtic and aic is ~ 2.4% and 23%, respectively.

temozolomid je triazén, ktorý pri fyziologickom ph podlieha rýchlej chemickej konverzii na aktívny monometyl-triazenoimidazol-karboxamid mtic.
temozolomide is a triazene, which undergoes rapid chemical conversion at physiologic ph to the active monomethyl triazenoimidazole carboxamide (mtic).

mtic sa spontánne hydrolyzuje na 5-aminoimidazol-4- karboxamid (aic), známy medziprodukt pri biosyntéze purínu a nukleovej kyseliny a na metylhydrazín, ktorý sa považuje za účinnú alkylačnú zložku.
mtic is spontaneously hydrolyzed to 5-amino-imidazole-4- carboxamide (aic), a known intermediate in purine and nucleic acid biosynthesis, and to methylhydrazine, which is believed to be the active alkylating species.