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medsebojno delovanje s p-glikoproteinom
p-glycoprotein interactions

in vitro študije s p-glikoproteinom
in vitro studies with p-glycoprotein

digoksin (s p- glikoproteinom posredovani prenos):
digoxin (p-glycoprotein mediated transport):

medsebojno delovanje s p-glikoproteinom (p-gp)
p-glycoprotein (p-gp) interactions

torej linagliptin ne zavira s p-glikoproteinom posredovanega prenosa in vivo.
therefore, linagliptin is not an inhibitor of p-glycoprotein-mediated transport in vivo.

deksametazon se prenaša s p-glikoproteinom (ki je znan tudi kot mdr1).
dexamethasone is transported by the p-glycoprotein (also known as mdr1).

lidokain se veže na plazemske beljakovine (66 %), vključno z alfa-1-kislim glikoproteinom.
lidocaine is reported to be 66% bound by plasma proteins, including alpha-1-acid glycoprotein.

Študije in vitro so pokazale, da ni pričakovati, da bi ataluren zaviral prenos s p-glikoproteinom ali presnovo s citokromom p450.
based on the in vitro studies, ataluren is not expected to be an inhibitor of neither p-gp mediated transport nor of cytochrome p450 mediated metabolism.

asenapin se v velikem odstotku (95 %) veže na plazemske beljakovine, vključno z albuminom in α1-kislim glikoproteinom.
asenapine is highly bound (95 %) to plasma proteins, including albumin and α1-acid glycoprotein.

interakcija je morda posledica tega, da ritonavir, odmerjan kot protiretrovirusno zdravilo ali farmakokinetični stopnjevalec, spremeni s p-glikoproteinom posredovani iztok digoksina.
this interaction may be due to modification of p-glycoprotein mediated digoxin efflux by ritonavir dosed as an antriretroviral agent or as a pharmacokinetic enhancer.

dajanje zdravila fuzeon posameznikom, ki niso okuženi z virusom hiv-1, lahko povzroči nastanek protiteles proti enfuvirtidu, ki navzkrižno reagirajo s hiv glikoproteinom 41.
administration of fuzeon to non-hiv-1 infected individuals may induce anti-enfuvirtide antibodies that cross-react with hiv gp41.

poleg tega je ugotovljeno, da je docetaksel aktiven na nekaterih, ne pa na vseh celičnih linijah s hipereksprimiranim p-glikoproteinom, ki ga kodira gen za rezistenco proti več zdravilom.
in addition, docetaxel was found to be active on some but not all cell lines over expressing the p-glycoprotein which is encoded by the multidrug resistance gene.

prašiči so bili vsaj dvakrat v presledku najmanj štirih mesecev serološko preiskani na prisotnost protiteles proti glikoproteinom adv-ge ali adv-gb ali adv-gd ali proti celemu virusu bolezni aujeszkega.
the pigs have been subjected on at least two occasions at an interval of at least four months to a serological survey for the presence of adv-ge or adv-gb or adv-gd antibody or to the whole aujeszky’s disease virus.

19 ambrisentan in vitro ni zaviral s p- glikoproteinom (pgp- p- glycoprotein) pogojenega efluksa digoksina in je šibek substrat za s pgp pogojeni efluks.
in vitro, ambrisentan has no inhibitory effect on the p-glycoprotein (pgp)-mediated efflux of digoxin and is a weak substrate for pgp-mediated efflux.