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darunavir was evaluated for carcinogenic potential by oral gavage administration to mice and rats up to 104 weeks.
44 darunavir er blevet vurderet for carcinogent potentiale ved peroral tvangsfodring af mus og rotter i op til 104 uger.
the test substance may be administered in the diet or in the drinking water, by gavage or in capsules.
stoffet, der skal undersøges, kan indgives via føden eller drikkevandet, ved hjælp af sonde eller i kapsler.
the test substance is administered in a single dose by gavage using a stomach tube or a suitable intubation canula.
teststoffet indgives ved gavage som én enkelt dosis med gastrisk sonde eller et passende intubationsrør.
the maximum volume of liquid that can be administered by gavage or injection at one time depends on the size of the test animal.
hvor stor en væskemængde, der kan indgives ad gangen ved tvangsfodring eller injektion, afhænger af forsøgsdyrenes størrelse.
the test substance is usually administered by gavage using a stomach tube or a suitable intubation cannula, or by intraperitoneal injection.
teststoffet indgives normalt ved tvangsfodring med sonde eller en passende intubationskanyle eller ved intraperitoneal injektion.
dosing with the test substance should normally be by the oral route using gavage, gelatine capsules, or a comparable method.
teststoffet bør normalt indgives oralt med mavesonde, gelatinekapsler eller en tilsvarende metode.
when the test chemical is administered by gavage, this should be done in a single dose to the animals using a stomach tube or a suitable intubation cannula.
hvis testkemikaliet indgives med sonde, skal det gøres i en enkelt dosis, med anvendelse af en mavesonde eller et passende intubationsrør.
a general clinical observation should be made each day and, and in the case of gavage dosing its timing should take into account the anticipated peak period of effects after dosing.
dyrene observeres dagligt klinisk, og ved sondeindgift foretages denne observation under hensyntagen til tidspunktet for den forventede maksimale virkning efter administrationen.
animals should additionally be checked once a day for specific signs of toxicological relevance, taking into consideration the peak period of anticipated effects after dosing in the case of gavage administration.
dyrene kontrolleres desuden en gang om dagen for specifikke tegn af toksikologisk relevans, idet man tager i betragtning, hvornår maksimal effekt kan forventes efter sondeindgift.
for a chemical administered by gavage, the dose should be given at similar times each day, and adjusted as necessary to maintain a constant dose level in terms of animal body weight.
ved administration med sonde skal dosis gives på tilsvarende tidspunkt hver dag og efter behov justeres, så dosisniveauet holdes konstant i forhold til kropsvægten.
long—term studies by gavage and in drinking water are either in progress or planned in rats and mice as well as repeat long—term inhalation studies in rats and mice.
langtidsundersøgelser med indgivelse ved tvangsfodring og i drikkevand i rotter og mus er enten i gang eller planlagt; det samme gælder gentagne langtidsinhaleringsundersøgelser i rotter og mus.
the test substance is administered by gavage or via the diet or drinking water. the method of oral administration is dependent on the purpose of the study, and the physical/chemical properties of the substance.
teststoffet indgives med mavesonde, i foderet eller i drikkevandet, afhængigt af formålet med forsøget og stoffets fysisk-kemiske egenskaber.
available toxicity data include the results of a 1-month oral gavage study in the rat, a 90-day feeding study in the rat and mutagenicity assays covering different genotoxic endpoints.
de foreliggende toksicitetsdata omfatter bl. a. resultaterne af et enmåneds oralt sondeforsøg i rotter, et 90dages fodringsforsøg i rotter samt mutagenicitetstests omfattende forskellige genotoksiske virkningsmekanismer.
general clinical observations should be made at least once a day, preferably at the same time(s) each day, taking into consideration the peak period of anticipated effects after dosing in the case of gavage administration.
almindelig klinisk observation bør foretages mindst én gang om dagen, fortrinsvis på samme tidspunkt(er), idet man tager i betragtning, hvornår maksimal effekt kan forventes efter sondeindgift.
in newborn rats receiving daily carglumic acid by oral gavage for 18 days as well as in young rats receiving daily carglumic acid for 26 weeks, the no observed effect level (noel) was established at 500 mg/ kg/ day and the no observed adverse effect level (noael) was established at 1000 mg/ kg/ day.
hos nyfødte rotter, der fik daglig cargluminsyre ved oral gavage i 18 dage såvel som hos unge rotter, der fik daglig cargluminsyre i 26 uger, blev der fastlagt en no observed effect level (noel) ved 500 mg/ kg/ dag og en no observed adverse effect level (noael) blev fastlagt ved 1000 mg/ kg/ dag.