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selain itu, aktiviti sel pembunuh semula jadi dalam kelawar dikekang akibat peningkatan pengawalaturan reseptor sel pembunuh semula jadi rencatan nkg2/cd94 dan tahap ekspresi yang rendah untuk molekul kelas 1 kompleks histokeserasian utama.
besides, the natural killer cell activity in bats is suppressed due to upregulation of inhibitory natural killer cell receptor nkg2/cd94 and low expression level of major histocompatibility complex class i molecules.
dna pengawalaturan 5' twist hanya mengandungi dua tapak pengikat dorsal afiniti rendah. oleh itu, kepekatan protein dorsal yang tinggi diperlukan untuk pengekspresan gen twist dan ini menyebabkan pengekspresan gen twist adalah terhad pada kawasan ventral nukleus.
the twist 5' regulatory dna contains two low-affinity dorsal-binding sites that are occupied onlyby peak levels of the dorsal gradient. as a result, twist expression is restricted to ventral nuclei.
kesimpulannya, corak dorsoventral awal embrio drosophila ditentukan oleh sifat-sifat intrinsik tapak pengikatan dorsal, serta interaksi protein-protein antara dorsal dan protein pengawalaturan lain yang terikat kepada enhancer sasaran.
in conclusion, the dorsoventral patterning of the early drosophila embryo and occupancy of dorsal-binding sites is determined by the intrinsic affinities of the sites, as well as protein–protein interactions between dorsal and other regulatory proteins bound to the target enhancers.