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(1983) rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.
(1983) rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.
Última atualização: 2016-03-03
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==research===== discovery of pi-3-kinase and ptdins(3,4,5)p3 ===in a series of studies spanning several years, cantley and colleagues demonstrated that a kinase activity associated with the middle t oncoprotein is a phosphoinositide kinase, that it is a novel type of phosphoinositide kinase that phosphorylates the 3' position on the inositol ring, and that this phosphatidylinositol-3-kinase (pi-3-kinase) is activated by growth factors to produce novel 3'-phosphorylated phosphoinositides, in particularly ptdins(3,4,5)p3.
==research===== discovery of pi-3-kinase and ptdins(3,4)p2 ===in a series of studies spanning several years, cantley and colleagues demonstrated that a kinase activity associated with the middle t oncoprotein is a phosphoinositide kinase, that it is a novel type of phosphoinositide kinase that phosphorylates the 3' position on the inositol ring, and that this phosphatidylinositol-3-kinase (pi-3-kinase) is activated by growth factors to produce novel 3'-phosphorylated phosphoinositides, in particularly ptdins(3,4,5)p3 that had previously been identified in physiologically stimulated human neutrophils.
Última atualização: 2016-03-03
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