You searched for: hypometylering (Danska - Engelska)

inkorporering af azacitidin i dna resulterer i inaktivering af dna-metyltransferaser, hvilket fører til hypometylering af dna.
incorporation of azacitidine into dna results in the inactivation of dna methyltransferases, leading to hypomethylation of dna.

virkningsmekanisme det vurderes, at azacitidin udøver sine antineoplastiske virkninger ved flere mekanismer, herunder cytotoksicitet på abnorme hæmatopoietiske celler i knoglemarven og hypometylering af dna.
mechanism of action azacitidine is believed to exert its antineoplastic effects by multiple mechanisms including cytotoxicity on abnormal haematopoietic cells in the bone marrow and hypomethylation of dna.

det er ikke fastlagt, hvordan vægtningen af azacitidins forskellige effekter på henholdsvis dna-hypometylering, cytotoksicitet og andre virkninger kan relateres til de kliniske resultater.
the relative importance of dna hypomethylation versus cytotoxicity or other activities of azacitidine to clinical outcomes has not been established.

dna-hypometylering af afvigende metylerede gener, der er involveret i regulering af normal cellecyklus, differentiering og celledød, kan resultere i reekspression af genet og genopretning af cancersupprimerende funktioner til cancerceller.
dna hypomethylation of aberrantly methylated genes involved in normal cell cycle regulation, differentiation and death pathways may result in gene re-expression and restoration of cancer- suppressing functions to cancer cells.

decitabin (5-aza-2-deoxycytidin) er et cytidindeoxynukleosid-analog, som i lave doser selektivt hæmmer dna-methyltransferaser, hvilket resulterer i genaktiverende hypometylering, der kan føre til genaktivering af tumorundertrykkende gener, induktion af celledifferentiering eller fremadskridende aldring af celler efterfulgt af programmeret celledød.
decitabine (5-aza-2-deoxycytidine) is a cytidine deoxynucleoside analogue that selectively inhibits dna methyltransferases at low doses, resulting in gene promoter hypomethylation that can result in reactivation of tumour suppressor genes, induction of cellular differentiation or cellular senescence followed by programmed cell death.