You searched for: klastogenost (Slovenska - Engelska)

klastogenost se sklada z znano farmakologijo olapariba in kaže na potencialno genotoksičnost pri človeku.
this clastogenicity is consistent with the known pharmacology of olaparib and indicates potential for genotoxicity in man.

pozitivno kontrolo za klastogenost in anevgenost je treba uporabiti pri celicah, pri katerih uporaba s9 ni potrebna.
pc for both clastogenicity and aneugenicity should be used in cells that do not require s9.

manjši presnovek tfma (4-trifluorometilanilin) je povzročil mutagenost in klastogenost in vitro, vendar ne in vivo.
the minor metabolite tfma (4-trifluoromethylaniline) caused mutagenicity and clastogenicity in vitro but not in vivo.

klastogenost, opaženo in vitro, so prišteli posrednim učinkom zaradi neravnovesja nukleotidne rezerve, ki je posledica farmakologije zaviranja dho- dh.
clastogenicity observed in vitro was considered to be an indirect effect related to nucleotide pool imbalance resulting from the pharmacology of dho-dh inhibition.

navesti je treba rezultate testov mutagenosti in vitro (bakterijski preskus za gensko mutacijo, test za klastogenost v celicah sesalcev in test za gensko mutacijo v celicah sesalcev).
results of in vitro mutagenicity tests (bacterial assay for gene mutation, test for clastogenicity in mammalian cells and test for gene mutation in mammalian cells) must be provided.

predložiti je treba rezultate preskusov in vitro za mutagenost (preskus genskih mutacij na bakterijah, preskus za klastogenost v celicah sesalcev in preskus genskih mutacij v celicah sesalcev).
results of in vitro mutagenicity tests (bacterial assay for gene mutation, test for clastogenicity in mammalian cells and test for gene mutation in mammalian cells) must be provided.

toda eden od stranskih presnovkov, tfma (4-trifluorometilanilin) je in vitro povzročil klastogenost in točkaste mutacije; za oceno možnosti za pojav tega učinka in vivo pa ni na voljo dovolj informacij.
however, the minor metabolite tfma (4-trifluoromethylaniline) caused clastogenicity and point mutations in vitro, whilst insufficient information was available on its potential to exert this effect in vivo.