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dopaminerga utskott från mellanhjärnan till framhjärnan gyrus cinguli striatum prefrontala barken substantia nigra accumbenskärnan ventrala tegmentala arean
note: meso-corticolimbic dopaminergic neurons from the ventral tegmental area and substantia nigra project to an important structure of the reward circuitry, the nucleus accumbens, and to the cortical areas primarily responsible for making decisions, such as whether to use drugs (e.g. the prefrontal cortex, and the cingulate gyrus).

utskott från mellanhjärnan ansluter också till nucleus caudatus och putamen (som har beteckningen striatum i figuren). källa: (hyman och medarbetare, 2006).
ethical concerns would arise if new therapies were disproportionately targeted on those in custody and other treatments of proven efficacy denied.